Washington University

Beth Israel Deaconess Medical Center, Inc.

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Herbert Virgin, Iv

Dan H Barouch

Peter Abbink

David Huabin Wang

Sarkis K Mazmanian

Yan Li

Gautam Dantas

Suxiang Tong

Guoyan Zhao

Stacy Finkbeiner

Jan Vinje

Hiutung Chu

Suryang Kwak

The present disclosure provides for engineered microorganisms and methods of making and using same. The engineered microorganisms as described herein can have a surface display and can be useful as therapeutic agents (e.g., sponges) and biosensors.

Engineered microorganisms and methods of making and using same

The present invention relates to recombinant adenoviruses and vectors thereof. In particular, the adenoviruses are novel simian adenoviruses having a low seroprevalence and high immunogenicity relative to other adenoviruses and vectors thereof. The invention also provides methods for production of the adenoviruses and for the treatment of diseases by administering the adenoviral vector(s) to a subject (e.g., a human).

Recombinant adenoviruses and use thereof

Among the various aspects of the present disclosure is the provision of a method of treating an inflammatory bowel disease. Another aspect provides the provision of a screening method for therapeutic agents. Another aspect provides a method of detecting Tcells to determine if a subject has an inflammatory disease. The present disclosure provides for methods of treatment, diagnosis, and screening for drugs for colitis and ileitis.

Methods and compositions for T cell generation and uses thereof

Provided herein is a novel human astrovirus, its nucleic acid sequence, as well as methods to detect and diagnose the presence of the astrovirus.

Identification of astrovirus VA1 associated with gastroenteritis in humans

Growing community of inventors

St. Louis, MO, United States of America

Herbert Virgin, Iv