Degussa Aktiengesellschaft

Asta Medica, Aktiengesellschaft

Herbert Tanner

Klaus Huthmacher

Frank Hubner

Friedhelm Geiger

Manfred Spindler

Steffen Krill

Karlheinz Drauz

Thomas Tacke

Jurgen Martens

Friedrich Bittner

Horst Bethge

Hans-Joachim Hasselbach

Roland Moller

Gerhard Sator

Claus Rehren

Klaus Hentschel

Jose Vanrobaeys

Gunes Giray

Martin Korfer

Klaus Willigerodt

Ferdinand Theissen

Sven-Peter Mannsfeld

Baudouin Halsberghe

Heinz Friedrich

Wolfgang Leuchtenberger

Dieter Greissinger

Harald Heinzel

Hermann Lotter

Hermann Schmitt

Bernd Drapal

Rainer Hahn

Volker Hafner

Klaus Stingl

Hans-Albrecht Hasseberg

Wolfram Binder

Winfried Heimbeck

Reinhard Richter

Heidrun-Leonore Bertram

Heidermarie Kniesel

Henning Holldorff

The invention relates to an improved method for the production of 2,3,5-trimethylhydroquinone by rearranging 4-oxo-isophorone (keto-isophorone, 3,5,5-trimethylcyclohex-2-en[e]-1,4-dione) to a trimethylhydroquinone diester and by its subsequent saponification. ##STR1##

Method for the production of trimethylhydroquinone

A method of producing 3,5,5-trimethylcyclohexa-3-ene-1-one (.beta.-isophorone) including a catalyst of an oxide or mixed oxide of at least one element of the groups IIa, VIII, Ib, IIIa and Va of the periodic system. Isomerization is carried out without the addition of an organic base. The space-time yield in the production of .beta.-isophorone by the isomerization of .alpha.-isophorone is at a level suitable for an industrial application. .beta.-isophorone is especially suitable as an intermediate product for producing ketoisophorone.

Method of producing 3, 5,

A process for the preparation of methionine or a salt of methionine by reaction of the components 3-methylmercaptopropionaldhyde, hydrogen cyanide, ammonia and carbon dioxide or components from which the above-mentioned components can be prepared, optionally in the presence of water, to 5-(2-methylmercaptoethyl)-hydantoin and further reaction thereof to methionine or the salt thereof, characterised in that the reaction of the components is initiated by means of at least one premixture in such a way that a first mixture is formed containing at least the predominant proportion (at least 5/10) of the 3-methylmercaptopropionaldeyde and at least 1/10 of the hydrogen cyanide component or corresponding quantities of components from which these components can be prepared, and less than 5/10 of one of the components ammonia, carbon dioxide or of the components from which ammonia or carbon dioxide can be prepared, and in that this first mixture is combined with the other component(s) for the reactive conversion to 5-(2-methylmercaptoethyl)-hydantoin, wherein this (these) latter component(s) may be premixed in one or more other mixtures.

Process for the preparation of D,L-methionine or the salt thereof

The present invention is relative to a method of producing dry thioctic acid in which a raw material in which concentrated thioctic acid is present is treated with liquid or supercritical CO.sub.2, thus yielding thioctic acid with low residual solvent contents in a simple industrial method.

Method of producing dry thioctic acid

Process for recovering 2-hydroxy-4-methylthiobutyric acid (MHA), MHA and

There is provided a process for the work-up of this material having the formula ##STR1## because of its poor crystallizability has heretofore been available only with large yield losses. The yield losses are due to the fact that the crystals of this compound are associated with large amounts of residual solvent material which gives rise to complex and expensive drying procedures. In accordance with the present invention the crude LPE is dried by means of fluid or supercritical carbon dioxide which maces it possible to reduce drying times from the previous range of about 124 hours to about 10 hours for the same amount of product and thus produce a dry LPE which has smaller amounts of residual solvent, as well as smaller by-products than that obtained by conventional drying.

Process for the preparation of 1-(N 2-(S)-ethoxycarbonyl)--3

A method of producing 3,5,5-trimethylcyclohexa-3-ene-1-one (.beta.-isophorone) by isomerization of 3,5,5-trimethylcyclohexa-2-ene-1-one (.alpha.-isophorone) in a liquid phase in the presence of a homogeneous or heterogeneous catalyst in which a mixture with a relatively low concentration of .beta.-isophorone is drawn off from the reaction container and the .beta.-isophorone isolated by vacuum distillation. .beta.-isophorone is an important synthetic structural element for the production of carotinoids, vitamins and pharmaceutical products.

Method of producing .beta.-isophorone by the isomerization of

An animal feed supplement and processes for its production which provide an inexpensive, not excessively hygroscopic or sticky supplement amino acid whose content should be standardizable. The animal feed supplement is based on a fermentation broth and contains the predominant proportion of its contents, optionally with the exclusion of part of the biomass. The biomass is preferably present in an amount of at most 10% by weight in the dry state. Proteins are preferably present in a maximum amount of 10% by weight. For the production, the sugar content is adjusted to a maximum of 4 g/l during fermentation, at least towards the end thereof, and at least part of the biomass is optionally removed during the working up.

Animal feed supplement based on a fermentation broth amino acid, a

A dosage form for administering physiologically active substances to animals, especially ruminant animals. The dosage unit includes a core which contains the active substance and a coating. The coating has selected areas which are thinner than the average thickness of the coating and/or areas which are predetermined rupture sites. These thin areas or predetermined rupture sites are constructed and arranged so as to detach and/or rupture under the conditions which are present after oral administration of the dosage form. As a result, the delayed release of the physiologically-active substance is accelerated. For example, the coating may be formulated to not be affected in the first stomach of a ruminant but to rapidly disintegrate in the animal's second stomach.

Active-substance preparation for oral administration, especially to

To supplement feeds and industrially produced mixed feeds with L-lysine, there are used aqueous L-lysine solutions having a L-lysine content between 30 and 80 weight percent, preferably between 50 and 70 weight percent. In comparison with crystallized L-lysine, they are clearly more stable and in equimolar amounts show the same L-lysine activity as the known forms presently offered.

Use of Aqueous L-lysine solutions for supplementing feeds and

In place of using solid DL-methionine for supplementing mixed fodders there are used sodium or potassium methioninate solutions. In comparison to solid methionine they are more easily dosable and can be more easily homogeneously mixed with the remaining components. Employing equimolar amounts they show the same methionine activity as solid methionine.

Use of aqueous sodium or potassium methioninate solution for

Aqueous sodium methioninate solutions having a low content of sodium carbonate can be recovered from the crude hydrolysis mixture resulting from the saponification of 5-(.beta.-methylmercaptoethyl)hydantoin with 1.1 to 6 equivalents of sodium hydroxide and/or sodium carbonate by cooling the crude hydrolysis mixture to a temperature below 10.degree. C., separating off the precipitated sodium carbonate and concentrating the sodium methioninate solution remaining to 40 to 65 weight percent.

Process for the production of aqueous sodium methioninate solutions

Aqueous sodium methioninate solutions having a low content of sodium carbonate can be recovered from the crude hydrolysis mixture resulting from the saponification of 5-(.beta.-methylmercaptoethyl)-hydantoin with 1.1 to 6 equivalents of sodium hydroxide and/or sodium carbonate by distilling off the water from the crude hydrolysis mixture until the sodium methioninate content is 40 to 65 weight percent, and after cooling to at most room temperature separating off the precipitated sodium carbonate.

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Hanau, Germany

Herbert Tanner