Battelle Memorial Institute

Herbert S Bresler

Douglas E Boyd

David A Friedenberg

Samuel Colachis

Nicholas Annetta

Collin F Dunlap

Po-Hsu Chen

Ian W Baumgart

Steven Risser

Amy M Heintz

Alexander Morrow

John S Laudo

Daniel A Kramer

Erik W Edwards

Lawrence Bullen

Michael J Brooker

James F Mank

Jerry D Johnson

R Mark Gritz

Steven W Graves

Seongwon Hong

A functional electrical stimulation (FES) device includes electrodes arranged to apply functional electrical stimulation to a body part of the user. FES stimulation is performed by: receiving values of a set of user metrics for the user; receiving a target position of the body part represented as values for a set of body part position measurements; determining a user-specific energization pattern for producing the target position based on the received target position and the received values of the set of user metrics for the user; and energizing the electrodes of the FES device in accordance with the determined user-specific energization pattern. The determination may utilize an FES calibration database with records having fields containing: values of the set of user metrics for reference users; energization patterns; and values of the set of body part position metrics for positions assumed by the body part in response to applying the energization patterns.

Calibration of electrode-to-muscle mapping for functional electrical stimulation

Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

Methods for tailoring the refractive index of lenses

An automated blood or bodily fluid sampling machine for collecting, measuring and monitoring real time samples from test animals during dosing of the animals, automatically provides real-time adjustment of dosing during testing. Such automated blood or bodily fluid sampling is performed in tandem with implanted physiological monitoring devices to monitor biological and physiological parameters in restrained or freely-moving test animals. The real-time feedback provides for dosing adjustment within testing protocols.

Real time sampling, monitoring and exposure control of test animals

A tissue dissociation device () includes a container () having a sterile interior for holding the tissue to be dissociated and a liquid medium. The device () also includes a dissociation element (), inside the container (), for engaging the tissue to cause dissociation of the tissue. The device () also includes a resistive element (), inside the container (), for resisting movement of the tissue in response to the engagement by the dissociation element (). Relative motion between and the resulting resistance provided by the resistive element () allows the dissociation element () to effectively dissociate the tissue. A powered tissue dissociation device includes a power source operatively connected to the dissociation element () for causing the dissociation element () to move into engagement with the tissue.

Tissue dissociation device

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Bexley, OH, United States of America

Herbert S Bresler