Merck Patent Gesellschaft MIT Beschrankter Haftung

Gruenenthal Gmbh

Herbert Rupprecht

Klaus Unger

Stephan Zinzen

Wolfgang Kircher

Horst Kramer

A multi-layered film which contains an active substance and which is made of film-forming polymers. The film comprises at least one covering layer, at least one layer containing the active substance, and an adhesive layer. A method and apparatus for producing such a multi-layered film and a preferred use as a transmucosal galenic formulation are also disclosed.

Active substance-containing multi-layer film of hydrophilic polymers crosslinked in situ

A process for the incorporation of active materials into silicon dioxide-containing carrier materials, comprises encapsulating the active material with liquid polyalkoxysiloxane, polyorganoalkoxysiloxane or a mixture thereof and subsequently effecting hydrolytic polycondensation of the siloxane. The resultant enveloped active material has readily controllable release properties.

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Wuppertal, Germany

Herbert Rupprecht