Botanix Sb, Inc.

Tolmar Therapeutics, Inc.

Herbert Robert Brinkman

Masahito Watanabe

Kazuyoshi Marubayashi

John Milton Downing

Kevin Stuart McCann

A cocrystal containing the 1'R-diastereomer and the 1&#x2032;S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1&#x2032;R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.

Crystalline form of sofpironium bromide and preparation method thereof

A cocrystal containing the 1'R-diastereomer and the 1'S-diastereomer of sofpironium bromide at a ratio of 1:3 (Form CO), a crystal mixture (for example, Form B) containing Form CO and a crystalline form of the 1&#x2032;R-diastereomer (Form MN), and a method for preparing sofpironium bromide, which is suitable for manufacture of the crystal mixture are provided. Form CO and a crystalline form of sofpironium bromide containing Form CO (for example, Form B) have superior stability without hygroscopic property, and accordingly they can be preferably used as a raw material of medicaments.

A cover plate for use in lyophilization processes is provided. The cover plate includes a base portion and a plurality of protuberances which project from the base portion. The protuberances are adapted to fit in one or more delivery containers, such as syringe barrels. The cover plate permits the escape of vapor from the one or more delivery containers during a lyophilization process. In addition, the cover plate prevents the escape of lyophilizate from the one or more delivery containers during a lyophilization process. Vent features provided to provide enhanced and preferred venting operations during lyophilization processes.

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Fort Collins, CO, United States of America

Herbert Robert Brinkman