Boehringer Ingelheim Gmbh

Boehringer Ingelheim Kg

C. H. Boehringer Sohn

Herbert Merz

Klaus Stockhaus

Adolf Langbein

Gerhard Walther

Matthias Grauert

Joachim Mierau

Hanfried Baltes

Wolfgang Hoefke

Claus S Schneider

Werner Traunecker

Walter Losel

Rainer Sobotta

Gunter Schingnitz

Rudolf Bauer

Helmut Wick

Werner Stransky

Helmut Ensinger

Hans Michael Jennewein

Ilse Streller

Enzio Mueller

Franz J Kuhn

Rolf Banholzer

Adrian Carter

Leon I Goldberg

Ingrid Wiedemann

Kalus Stockhaus

Gerard Walther

A process for the re-racemisation of a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative wherein a (-)-2-phenylmethyl-3,3-dimethyl-piperidin-4-on derivative of the formula 8.sub.B wherein

Heat-based process for the re-racemisation of a

The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2'R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R, 6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-me thano-benzo[.alpha.]oxacin-9-ol] (BIII 277).

Method of preparing norbenzomorphane as an intermediate in the

The present invention relates to new processes for preparing norbenzomorphan, the central intermediate step in the preparation of pharmaceutically useful benzomorphan derivatives of general formula 1 ##STR1## especially (-)-(1R,5S,2'R)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomo rphan or [(-)-(2R,6S,2'R)-3-(2-methoxypropyl)-6,11,11-trimethyl-1,2,3,4,5,6-hexahyd ro-2,6-methano-benzo[.alpha.]oxacin-9-ol] (BIII 277).

Method of preparing norbenzomorphane as an intermediate

Method of preparing norbenzomorphanes

Novel benzomorphan derivatives of the formula ##STR1## wherein R.sup.1 -R.sup.8 are as defined herein. The benzomorphan derivatives are useful for treating cerebral ischaemia of various origins, epilepsy and neurodegenerative diseases.

Benzomorphan derivatives

Useful for treating neurodegenerative diseases

The present invention relates to 14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine, processes for preparing them and their use as pharmaceutical compositions.

14-hydroxy-N-(2-methoxyethyl)-7,8-dihydromorphine and -norisomorphine,

The invention relates to novel 2,5-diaminotetralines of the formula: ##STR1## wherein R1, R2, R3 and R4 are defined herein, processes for preparing them and their use in pharmaceutical compositions. The novel 2,5-diaminotetralines are useful in treating diseases caused by disorders of the dopaminergic systems.

Method of treating disorders of the dopaminergic systems using

Novel compounds having the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. These compounds are useful in the treatment of schizophrenia.

Use of 2,7-diamino-1,2,3,4-tetrahydronaphthalenes as medicaments, new

3-Bromo-2,6-dimethoxybenzamides useful as neuroleptic agents are described.

Certain 3-bromo-2,6-dimethoxybenzamides and pharmaceutical use thereof

Tetrahydrobenzothiazole derivatives of the formula ##STR1## wherein n is 1, 2 or 3 and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are defined substituents, said derivatives (I) being suitable as active compounds for treating parkinsonism or Parkinson's Disease.

Tetrahydrobenzothiazoles, and the preparation and use thereof

The compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compound as well as its salts are useful as analgesics.

N-(3-trifluoromethyl-phenyl)-N'-propargyl-piperazine and salts thereof

The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.

N-(2-methoxyethyl)-noroxymorphone and pharmaceutical compositions for

Compounds of the formula ##STR1## wherein Ar is ##STR2## R.sub.1 is hydrogen, fluorine, bromine, methyl or methoxy; X is .dbd.CO, .dbd.CH--CN, .dbd.CH--OH, --O--, --S--, --NH--, ##STR3## and R is hydrogen, 4-fluoro, 4-chloro, 4-trifluoromethyl, 3-trifluoromethyl, 3-trifluoromethyl-4-chloro, 4-methyl or 4-methoxy; and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as neuroleptics.

8-Arylalkyl-3-phenyl-3-nortropanols and salts thereof

Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl;

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Ingelheim am Rhein, Germany

Herbert Merz