International Minerals & Chemical Corp.

Imc Chemical Group, Inc.

Commercial Solvents Corporation

Herbert L Wehrmeister

Jing-jong Lu

Novel dihydroisoxazole compounds are disclosed having activity against parasitic worms and showing little or no toxicity to the host animal. These compounds are 3-chloro-4-dialkylaminophthaloylamino-4,5-dihydroisoxazoles and 3-dialkylamino-4-dialkylaminophthaloylamino-4,5-dihydroisoxazoles. A process for making these compounds and a method of administering them to infested animals is also disclosed.

Process for preparing phthalimido isoxazoles

Novel phthalamide compounds are disclosed having activity against a broad spectrum of parasitic worms and showing no toxicity to the host animal. These compounds are N-(3-chloro-4,5-dihydroisoxazol-4-yl)-N'-(substituted)phthalamides. A process for making these compounds and a method of administering them to animals are also disclosed.

Phthalamide derivatives with anthelmintic activity

A novel tolylthioisoxazole compound is disclosed having activity against the pinworms S. obvelata and A. tetraptera. A process for making these compounds and a method of administering it to infested animals is also disclosed.

3-tolylthio-4-amino-4,5-dihydro isoxazole as anthelmintic

Dihydroisoxazole compounds and anthelmintic use

Certain phenylthioalkylamines and amides thereof are antifungal or antibacterial agents, or both, and provide a method of controlling the growth of these microorganisms.

Antimicrobial agents

A method of controlling the growth of microorganisms by using a compound represented by the formula ##STR1## wherein R is hydrogen or methyl, R.sup.1 is hydrogen, methyl or ethyl, or R and R.sup.1 can collectively be a cyclic alkyl group of 5 carbon atoms.

Method of controlling the growth of microorganisms using nitroalkyl

The product prepared by the process consisting of the steps of (a) reacting a nitroalcohol of the formula ##STR1## where R and R.sup.1 can be hydrogen, methyl, ethyl or hydroxymethyl in about a 1:1 mole ratio with an alkylamine represented by the formula R.sup.2 NH.sub.2 where R.sup.2 is alkyl of from 1 to 4 or more carbon atoms or phenyl, benzyl, toluyl, or xylyl at about 50.degree.-70.degree. thereby effecting formation of a nitroalkylamine; (b) reacting the nitroalkylamine with nitrous acid at about 0.degree.-5.degree., thereby forming a nitroso compound; and (c) reducing the nitroso compound.

Method of controlling the growth of bacteria and fungi

Nitrosamine reaction products for controlling the growth of bacteria and

Carbostyril derivatives useful as coccidiostats are prepared by reacting an ortho-halo benzaldehyde with a 2-alkyl-2-oxazoline, then heating at above about 200.degree. C thereby forming the carbostyril.

Method for preparing carbostyril derivatives

A method for combatting coccidiosis in poultry by orally administering thereto a substituted quinoline or a compound represented by the formula ##STR1##

Coccidiostats

Carbostyril derivatives used as coccidiostats

Tranquilizing agents for warm-blooded animals corresponding to the formula ##EQU1## where n can be 1 or 2; Y can be ##EQU2## where R.sup.2 can be hydrogen or an alkyl, alkenyl, alkoxy, phenyl or methoxyphenyl radical. Z can be thienyl, furyl, phenyl; or mono-, di-, or trimethoxyphenyl; mono-, or dichlorophenyl, or dichlorophenoxy. R and R.sup.1 can be hydrogen, methyl, or ethyl and can be the same or different.

Growing community of inventors

Terre Haute, IN, United States of America

Herbert L Wehrmeister