Qiagen Gmbh

Chemotherapeutisches Forschunginstitut Georg-speyer-haus

Chemotherapeutisches Forschunginstitut Georg Speyer-haus Zu Frankfurt

Herbert Kuhnel

Helga Rubsamen-Waigmann

Hagen Von Briesen

Ursula Dietrich

Michalina Adamski

Karsten Henco

Andreas Immelmann

Vaccine for protection against HIV infections, therapeutic agents for treatment subsequent to HIV infections, process for their preparation and their use; procedure for differentiation between HIV-2.sub.ALT type infections and HIV-2 infections defined by the prototype HIV-2.sub.ROD. Subject matter of the present invention are the virus HIV-2.sub.D205 as well as HIV-2 variants distinguishing from the HIV-2 prototypes of the type HIV-2.sub.ROD in that nucleotide sequence homology is less than 77%. Further, proteins and nucleic acids of HIV-2.sub.D205 and its variants for utilization as vaccines for protection against HIV infections, for geno- or immunotherapy, for establishing an animal model, and for differential diagnostics are part of this invention. Furthermore, the processes for preparing these vaccines, immunotherapeutic and diagnostic agents as well as their use are part of this invention.

Vaccine for protection against HIV infections, process for preparing

HIV-2 virus variants, namely virus HIV D194 and virus HIV D205, which can be cloned from the corresponding virus isolate HIV D194 (ECACC V 87122303) or from the infected cell line HUT 194 (ECACC V 87122306) or from the virus isolate HIV D205 (ECACC V 87122304), respectively, and their RNA or RNA-fragments and DNA and DNA-fragments derived therefrom and/or proteins and the use thereof for diagnostics and therapy.

HIV-2 virus variants

Growing community of inventors

Egelsbach, Germany

Herbert Kuhnel