Boehringer Ingelheim Gmbh

Boehringer Ingelheim Kg

C. H. Boehringer Sohn

Boehringer Ingelheim International Gmbh

Herbert Koppe

Werner Kummer

Helmut Stahle

Wolfgang Hoefke

Gojko Muacevic

Ludwig Pichler

Werner Traunecker

Christian Lillie

Walter Kobinger

Klaus Stockhaus

Karl Zeile

Kurt Schromm

Ernst-Otto Renth

Anton Mentrup

Wolfram Gaida

Albrecht Engelhardt

Richard Reichl

Walter Haarmann

Franz Esser

Franz J Kuhn

Peter Danneberg

Dietrich Arndts

Walter Kobinge

Werner Taunecker

Rolf Giesemann

Franz Josef Kohn

Gojko Muaceic

Wolfgang Abele, Deceased

Wolfgang Abele

Compounds of formula ##STR1## (the substituents R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are explained in the specification) may be prepared by conventional methods. Owing to their favorable activity profile the compounds may advantageously be used to treat certain heart and circulatory disorders.

1-phenoxy-3-amino-2-propanols use thereof

The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;

1-(Alkanoylamino-aryloxy)-2-hydroxy-3-(alkinyl-amino)-propanes and salts

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;

Intermediate 1-alkylenyl-1H-benzimidazol-2-one derivatives

Disclosed are novel compounds having the formula ##STR1## wherein R.sub.1 is a hydrogen or halogen atom, a lower alkyl, lower alkoxy, lower alkoxy lower alkyl, lower alkenyl, lower alkenyl oxy, cyano, hydroxy, trifluoromethyl, nitro, amino, aminocarbonylmethyl, lower monoalkylamino, lower dialkylamino group;

1-aryloxypropanolamines

Compounds of the formula ##STR1## wherein X, Y and Z are each independently hydrogen, halogen, lower alkyl, halo(lower alkyl), lower alkoxy, halo(lower alkoxy), (lower alkyl)thio or halo(lower alkyl)thio, or

Analgesic 1-acetonyl-2-(phenylimino)-imidazolidines and salts thereof

##STR1## wherein R.sub.1 is straight or branched alkyl of 1 to 4 carbon atoms;

5-Anilino-1,2,3-triazole-4-carboxylic acid compounds

Compounds of the formula ##STR1## wherein R is bromine or trifluoromethyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs, analgesics and locomotion inhibitors.

Bradycardiac or analgesic

This invention relates to substituted imidazo[1,2-a]imidazoles and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.

Imidazo[1,2-a]imidazoles in the treatment of pain, hypertonia and

Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkenyloxy, lower alkinyl, nitro, trifluoromethyl, hydroxyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, acyl, acyloxy, nitro, trifluoromethyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the aryl ring;

1-Aryloxy-3-alkinylamino-propan-2-ols

Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring;

1-Aryloxy-3-alkylamino-propan-2-ols

This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents a linear or branched alkyl of from 1 to 20 carbon atoms;

1-Aryloxy-3-alkylamino-2-propanols and pharmaceutical compositions

This invention relates to substituted imidazo[1,2-a]pyrimidines and non-toxic, pharmaceutically acceptable salts thereof. These compounds are useful in relieving pain and in treating hypertonia and coronary diseases.

Substituted imidazo[1,2-a]pyrimidines and pharmaceutical compositions

Compounds of the formula ##STR1## wherein R is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as bradycardiacs.

Substituted

1-Aryloxy-2-hydroxy-3-((heterocyclic-substituted alkyl)-amino)-propanes

Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3, which may be identical to or different from each other, are each hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, hydroxyl or amino;

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Ingelheim am Rhein, Germany

Herbert Koppe