Garvan Institute of Medical Research

Herbert Herzog

Charles Reay Mackay

John Shine

Lisa Selbie

The present invention provides transgenic animals having a reduced level of expression of peptide YY (PYY) and drug screening platforms using the transgenic animals for identifying agonists and antagonists of PYY. The present invention further provides monoclonal antibodies that bind specifically to full-length PYY[1-36] or the processed form thereof i.e., PYY[3-36] and to diagnostic and drug screening platforms using the monoclonal antibodies. The invention has particular utility for the diagnosis of a predisposition or risk of a subject becoming obese, developing one or more pathologies associated with obesity, or developing a disease/disorder of bone tissue.

Modified animal lacking functional PYY gene, monoclonal antibodies that bind PYY isoforms and uses therefor

The invention provides isolated polynucleotide molecules encoding a novel neuropeptide Y (NPY) receptor (designated NPY-Y7). These isolated polynucleotide molecules can be used to express the receptor in cells which can then be used to screen compounds for agonist and antagonist activity.

NPY-Y7 receptor gene

The invention provides isolated polynucleotide molecules encoding a novel neuropeptide GABA-B receptor (designated GABA-B). These isolated polynucleotide molecules can be used to express the receptor in cells which can then be used to screen compounds for agonist and antagonist activity.

GABA-B2 receptor

The present invention relates to isolated polynucleotides encoding novel PY peptides, and to isolated PY peptides and functionally equivalent fragments thereof. The PY peptides of the present invention may be useful in regulating central and peripheral nervous and endocrine systems.

NPY family member

The invention provides isolated DNA molecules encoding the human, mouse and rat NPY-Y5 receptors. These isolated DNA molecules can be used to express the NPY-Y5 receptors in cells which can then be used to screen compounds for NPY agonist and antagonist activity.

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Bondi, Australia

Herbert Herzog