Research Triangle Institute

Duke University

Temple University

University of California

Herbert H Seltzman

Yanan Zhang

Alan Bradley Fulp

Rangan Maitra

Lawrence S Barak

Mary E Abood

Pingwei Zhao

Yung-Ao Hsieh

Brian Frazier Thomas

Craig Shiner

Igor Spigelman

Maria Elena Y Francisco

Peripherally acting cannabinoid agonist compounds, pharmaceutical compositions, and methods of using them are presented.

Peripherally-acting cannabinoid receptor agonists for chronic pain

Compounds are provided having agonistic activity against G protein-coupled receptor 35 (GPR35). The compounds are useful for providing antinociception, providing neuroprotection in case of stroke or ischemia, or treating gastric inflammation.

Treatment of disorders associated with G protein-coupled receptor 35 (GPR35)

The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation.

Peripherally restricted diphenyl purine derivatives

The invention provides compounds capable of acting as antagonists at cannabanoid receptors according to the following formula: Such compounds may be used to treat conditions for which the cannabinoid receptor system has been implicated, such as obesity, liver disease, diabetes, pain, and inflammation. 

Pyrazole derivatives as cannabinoid receptor 1 antagonists

Compounds are provided that are amide analogs of SR141716A having unique CB1 receptor selectivity and providing WIN sparing binding characteristics, pharmaceutical compositions containing the compounds and their use in a method of treatment of CB1 receptor related disorders, such as obesity, schizophrenia, memory dysfunction and marijuana abuse.

Compounds having unique CB1 receptor binding selectivity and methods for their production and use

Aminomalonyl alanine compounds as dietary sweeteners

Compounds having relatively long shelf lives in acidic aqueous media and which are useful as sweeteners have the formula ##STR1## or are pharmaceutically acceptable salts thereof, wherein X is --OR or --NHR, or --NH.sub.2, with R being alkyl having 3-10 carbon atoms.

Growing community of inventors

Raleigh, NC, United States of America

Herbert H Seltzman