The Rockefeller University

Other

Symbiosis Corporation

Herbert Cohen

Brian T Chait

Andrew N Krutchinsky

Vadim Sherman

Markus Kalkum

Charles R Slater

Matthew S Solar

Frank A Scarfone

David H Turkel

Julio Padovan

George A Nunez

Jurgen A Kortenbach

David P Gordon

Thomas A Gallagher

An ion trap includes a containment region for containing ions, and a plurality of electrodes positioned on a regular polyhedral structure encompassing the containment region. An electrode is positioned on each vertex of the encompassing structure and at least one of the polygonal surfaces includes additional electrodes configured to form a plurality of quadrupoles on the surface. Alternating RF voltage is applied to the plurality of electrodes, so that directly neighboring electrodes are of equal amplitude and opposite polarity at any point in time. This configuration on the polyhedral structure forms a potential barrier for repelling the ions from each of the regular polygonal surfaces and containing them in the trap. Mass selective filters can be formed from the quadrupoles for parallel mass analysis in different m/z windows. Application of a small DC potential to a plate electrode outside the quadrupoles preferentially depletes single charged ions for enhanced signal-to-noise analysis.

Multi-pole ion trap for mass spectrometry

An ion transfer device for transferring ions emerging from an electrospray ion source at atmosphere to a vacuum chamber includes an inner surface in the shape of a diverging conical duct. The ion transfer device has an entrance aperture for positioning proximate the exit port of the electrospray ion source emitter, the entrance aperture receiving the electrosprayed ions from the exit port of the electrospray ion source emitter at atmosphere, the diverging conical duct being an electrode toward which the ions migrate and having an exit aperture with an inner diameter larger than an inner diameter of its entrance aperture, the exit aperture enclosed in the vacuum chamber, the diverging conical duct transporting the ions from atmosphere to vacuum. The vacuum chamber can be a chamber of a vacuum housing enclosing a mass analyzer.

Method and apparatus for improving ion transmission into a mass spectrometer

A method for manipulating ions in an ion trap includes storing ions, spatially compressing, and ejecting selected ions according to mass-to-charge ratio. An ion trap includes an injection port, an arm having a first and a second end for confining and spatially compressing the ions, and an ejection port for ejecting the ions from the second end. The arm includes two pairs of opposing electrodes, which provide a quadrupole electric field potential at any cross-section of the ion trap. The distance between opposing electrodes and the cross-sectional area of the electrodes increases from the first to second end. The electrodes may be tapered cylindrical rods or of hyperbolic cross-section. Ions selected for ejection are spatially compressed into a region at the second (wider) end. The ion trap may include one arm, with either orthogonal or axial ejection, or two arms with a central insert for orthogonal ejection.

Linear ion trap for mass spectrometry

The present invention is a method and system for investing with a no or low-loss assurance the aid of an agent. The invention provides a plurality of risk levels having a gain apportionment value and a lost apportionment value. The gain apportionment value dictates the apportionment of a gain between the investor and the agent, while the lost apportionment value dictates the apportionment of a loss between the investor and the agent. Each risk level also has a gain sale threshold and a loss sale threshold. The investor selects one of the risk levels. When one of the sale thresholds is reached, the equity is sold to complete a cycle or transaction of a combo, or combination of transactions. The investor's apportioned gain is added to an investor's money packet thereby increasing its value. A loss sale threshold ends the combo. The loss is apportioned between the investor and the agent according to the loss apportionment value of the selected risk level and the investors apportioned loss is subtracted from the money packet.

Method and system for investing with a no-loss or low-loss assurance

A system for determining the ratio of mass to charge of an ion including a pulsed ionizer, a high pressure co-linear ion guide/accelerator, and a mass analyzer. The pulsed ionizer generates intact analyte ions from a sample of matter to be analyzed. The high pressure co-linear ion guide/accelerator is interfaced with the ion source for receipt of the intact ions of the sample. The ion guide/accelerator simultaneously dampens and linearly accelerates the intact ions in the substantial absence of fragmentation of the ions to provide a substantially continuous beam of the intact ions for mass analysis. The mass analyzer is connected to the ion guide/accelerator for receipt of the beam of ions and determines the mass to charge ratio of the intact ions.

Method and system for mass spectroscopy

Method of transmitting ions for mass spectroscopy

A protected microbiological sampling brush assembly includes a sampling brush mounted on the distal end of a control wire, an inner catheter which houses the brush, an outer catheter which houses the inner catheter, and an elastomeric tip which is rigidly attached to the distal end of the outer catheter and which has a weakened end. The proximal ends of the control wire and catheters are coupled to a handle for independently moving the control wire, the inner catheter, and the outer catheter relative to each other. The weakened end of the elastomeric tip is preferably a slit which defines lips which are parted when the distal end of the inner catheter is moved distally against the elastomeric tip to allow the inner catheter to pass therethrough. When the inner catheter is moved proximally relative to the outer catheter, the lips of the elastomeric tip close to protect the inner catheter (and the sampling brush) from contamination. Easy to use handles which are attached to the proximal ends of the control wire, the inner catheter, and the outer catheter are disclosed.

Protected microbiological sampling brush assembly

An endoscopic irrigation instrument includes a fluid chamber, a cannula coupled to a distal end of the fluid chamber, a tapered irrigation tube which couples at its proximal end to a fluid source and which couples at its distal end to an irrigation port of the fluid chamber, and a pinch valve which controls the flow of fluid from the irrigation source to the fluid chamber and hence through the cannula to the surgical site. The tapered irrigation tube is arranged so that it has a first relatively larger constant inner diameter and relatively larger wall thickness on its proximal end until it tapers down in both inner diameter and wall thickness at a location slightly proximal the pinch valve. By the time the tapered irrigation tube passes the pinch valve in the endoscopic instrument, the tapered irrigation tube is at a second relatively smaller constant inner diameter and a relatively smaller wall thickness. The tapered irrigation tube thus enables greater fluid flow, pinch valve control at the thin distal end, and tube reliability at both high and low fluid pressures.

Flexible tube having a tapered diameter portion for use with endoscopic

An endoscopic instrument has a distal assembly removable from a proximal handle. The distal assembly includes a tube carrying an end effector and a push rod coupled to the end effector and slidable through the tube. The proximal handle includes a tube sleeve for receiving the tube, an actuator and a latch for coupling the push rod to the actuator. The tube sleeve is provided with a tube lock for holding the tube securely in place and the tube is provided with a circumferential groove for engaging the lock. The latch is spring loaded, hinged, and has an inclined surface for quick coupling with the push rod. The latch also has a mechanism for uncoupling the latch from the push rod. The push rod is provided with a mating tip which engages the latch so that the actuator causes reciprocal movement of the push rod within the tube to operate the end effector. An axially movable collar on the tube sleeve is used in unlatching, and in one arrangement is also used for rotating the distal assembly.

Endoscopic instruments having detachable proximal handle and distal

A trocar catheter includes a trocar rod having a stepped diameter distal end for use with a catheter having a stepped diameter lumen wherein the trocar is inserted into the lumen of the catheter and the trocar is used to incise a patient and install the catheter after which the trocar is removed from the lumen of the catheter. The distal end of the trocar rod is provided with a stepped coaxial bore into which a piercing point rod, a spring and a safety sleeve are assembled. The piercing point rod has a proximal small diameter portion which is press fit into a correspondingly small diameter portion of the coaxial bore in the distal end of the trocar rod. The spring is carried on the small diameter portion of the piercing point rod and biases the safety sleeve in a distal direction. The distal end of the piercing point rod has a larger diameter portion tapering to a piercing tip and the safety sleeve has a stepped inner diameter which prevents it from moving beyond a predetermined distal position covering the piercing tip. The stepped coaxial bore has a large diameter portion for receiving the safety sleeve when it is pressed proximally against the spring. A protrusion on the distal outer surface of the safety sleeve prevents the catheter from accidentally slipping off the trocar.

Growing community of inventors

New York, NY, United States of America

Herbert Cohen