Boehringer Mannheim Gmbh

Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

F. Hoffmann-La Roche Ag

Igen Ls LLC

Herbert Buschek

Sigmar Klose

Helmut Schlumberger

Klaus Erler

Hans-Georg Batz

Rupert Herrmann

Joachim Siedel

Manfred Kuhr

Manfred Pasch

Reinhold Krämer

Wolfgang Weckerle

Judith Pinsl-Ober

Michael Kuehnl

Wolfgang Kleemann

Friedhelm Vieth

Roland Ihrig

Wolfgang Kleeman

Rudolf Machat

Maria Cully

Petra Ickler

Michael Kühnl

A cell for conducting electrochemiluminescence measurements is disclosed. The cell in one embodiment provides a measurement cell housing having a cavity, a fluid inlet channel for inducing fluid into the cavity and a fluid outlet channel for discharging fluid from the cavity at axial ends. The cell also provides at least one working electrode and a counter electrode on or in the cavity, and an optical viewing element for observing electrochemiluminescence effects in the cavity, wherein the fluid inlet channel has an at least approximately continuous curved course in a transition area to the cavity so that the fluid inlet channel at its end which is joined to the cavity is shaped in such a manner as to constitute a continuous course of the transition between the fluid inlet channel and the cavity to generate a largely steady flow profile when inducing fluid into the measurement cell cavity.

Cell for conducting electrochemiluminescence measurements

There is provided a system for the preparation of liquids from at least one solid and at least one liquid phase. The system is composed of a vessel in which the solid or solids are located and a drying chamber which is connected to the vessel or can be connected to the vessel. The drying chamber is separated from the vessel interior by a separating means which is permeable to water vapour but is impermeable to liquids. The system is suitable for the production of liquids from moisture-sensitive solids. These solids can be stored in the vessel since the air humidity in the interior is lowered by the desiccant. The preparation of the liquid by addition of a liquid phase can be carried out in one and the same vessel since the desiccant is separated from the vessel interior.

Apparatus with desiccant chamber and method of using

Analysis system for the automatic analysis of body fluids for a plurality of different analytes (parameters). An analytical apparatus incorporates reaction vessels (8) which are transported on the apparatus to various handling stations (10 to 16). The system also includes liquid reagents, which are held in readiness on the apparatus in reagent vessels (9), their volume sufficing for a large number of analyses. In order to achieve a high degree of analytical accuracy with reduced probability of operating errors and without significant increasing of the overall system costs, a calibrator is stored ready for use in liquid form in a calibrator station (17) of the analytical apparatus, the calibration is initiated and carried out fully automatically (i.e. without human intervention) for the various parameters independently of one another. For the initiation of the calibration for a parameter, in at least one system-immanent calibration-influencing variable is determined and combined logically with a control value defined specifically for the respective parameter and the decision on the initiation of the calibration is taken automatically in accordance with the logic combination.

Analysis system for the automatic analysis of body fluids

The present invention provides phenolsulphonphthaleinyl-.beta.-D-galactosides of the general formula: ##STR1## wherein R.sup.1 to R.sup.4, which can be the same or different, are hydrogen or halogen atoms or nitro or amino groups, R.sup.5 to R.sup.12, which can be the same or different, are hydrogen or halogen atoms or lower alkyl, hydroxyl, lower alkoxy, carboxyl or nitro groups and M.sup.+ is a proton, an alkali metal, alkaline earth metal or ammonium ion. The present invention also provides a process for preparing these galactosides and diagnostic agents containing them.

Phenolsulphonphthaleinyl-.beta.-D-galactosides and diagnostic agents

A process and a device for the centrifugal control and mixing of a limited volumes of fluid, especially in the rotor of a centrifugal analyzer, has at least one baffle chamber, in a flow canal for the fluid the volume of which is greater than the volume of fluid. It is so shaped that, when the device is rotated at a sufficiently high first speed of rotation, the fluid remains in it. An outlet canal is connected to the baffle chamber the fluid. At least a part thereof lies closer to the axis of rotation than the fluid surface during the rotation with the first speed of rotation. The walls of the outlet canal consist of a material which is wettable by the fluid and, in combination therewith, have cross-section which forces the fluid out of the baffle chamber; by boundary surface force when the device is rotated at a second, slower speed.

Process and device for the control and mixing of a fluid current

The present invention provides a process for the stabilization of an aqueous solution of cholesterol esterase from Pseudomonas, especially in the presence of a surface-active agent, wherein the enzyme is dissolved in a phosphate-free buffer which contains 10 to 200 mMol/liter of magnesium ions.

Process for the stabilization of aqueous solutions of cholesterol

For the removal of turbidities in reaction mixtures clouded by sample material, especially for photometric measurement, there are added to the reaction mixture:

Compositions and method for reducing turbidity in samples

Growing community of inventors

Weilheim, Germany

Herbert Buschek