Boehringer Mannheim Gmbh

Herbert Brustmann

Erich Haid

Heinrich Traeger

Thomas Bergmann

The present invention provides a process for freeze drying of especially biologically or pharmaceutical material under sterile conditions, wherein the material to be dried is introduced into a container the sides of which consist at least partly of a hydrophobic, porous, micro-organism-impermeable, water vapor-permeable membrane, the container is tightly closed and the material is subsequently freeze dried in the closed container under the usual conditions. The present invention also provides a container for freeze drying materials under sterile conditions, wherein the sides of the container consist at least partly of a hydrophobic, porous, germ-impermeable, water vapor-permeable membrane.

Process and container for freeze drying under sterile conditions

The invention provides a novel crystalline potassium salt of .beta.-nicotinamide adenine dinucleotide phosphoric acid (.beta.-NADP-K), having a primitively orthorhombic crystal system, which salt is more pure and more stable than the conventional amorphous form, and is advantageously not hygroscopic. The novel salt is produced by treating a dilute aqueous solution of the potassium salt of .beta.-nicotinamide adenine dinucleotide phosphoric acid with a hydrophilic water soluble organic solvent at a pH value of 2 to 5 until turbidity sets in, permitting crystallization and then separating the crystals.

Crystalline potassium salt of .beta.-nicotinamide adenine dinucleotide

Crystalline orthorhombic potassium adenosine-5'-diphosphate having the space group P2.sub.1 2.sub.1 2 and the elemental cell constants

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Tutzing, Germany

Herbert Brustmann