Boehringer Mannheim Gmbh

Herbert Berger

Wolfgang Vomel

Rudi Gall

Winfriede Sauer

Kurt Stach

Alfred Rhomberg

Wolfgang Kampe

Kurt Stach, Deceased

Uwe Bicker

Max Thiel

Alfred Mertens

Klaus Strein

Bernd Muller-Beckmann

Elmar Bosies

Wolfgang Von Der Saal

Alfred Grafe

Rita Hoffmann

Egon Roesch

Jens-Peter Holck

Wolfgang Schaumann

Hartmut Merdes

By Werner Plattner, Administrator

Rolf Kuhn

By Werner Plattner, Executor

Gottfried Hebold

Werner Plattner, Administrator

Alfred Martens

Bernd Muller-Beckman

The present invention provides compounds of the general formula ##STR1## wherein the variables are as defined herein. The present invention also provides processes for the preparation thereof, pharmaceutical compositions containing them and intermediates for the preparation thereof.

Benzodipyrroles, processes for the preparation thereof and

The present invention provides Indolines of the formula: ##STR1## ps useful to provide pharmaceutically active pyrrolobenzimidazoles or tautomers thereof, of the formula:  These compounds are useful for treating heart or circulatory diseases, especially those which respond to a change of blood pressure, an increase in cardiac output and/or a change in micro-circulation.

Indoline compounds for synthesis of pharmaceutically active

The present invention provides benzimidazoles of the general formula: ##STR1## wherein R.sub.1, X, A, and R.sub.2 are as defined in the specification. The present invention also provides processes for the preparation of these new benzimidazoles and pharmaceutical compositions containing them, as well as intermediates for the preparation thereof. The new benzimidazoles are useful to treat heart or circulatory diseases which respond to a lowering of blood pressure, a positive inotropic action and/or an improvement in microcirculation.

Cardiotonic benzimidazoles

The present invention provides compounds of the general formula: ##STR1## wherein the various substituents are defined hereinbelow. The compounds are used for the treatment and/or prophylaxis of heart and circulatory diseases.

Tricyclic compounds for treating heart and circulatory diseases

The present invention provided pyrrolobenzimidazoles or tautomer thereof, of the general formula: ##STR1## wherein R.sub.1 is hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl or C.sub.3 -C.sub.7 cycloalkyl;

Pyrrolobenzimidazoles, pharmaceutical compositions containing them and

A 2-cyanaziridine derivative of the formula ##STR1## wherein R' is a straight-chained or branched, saturated or mono- or polyunsaturated aliphatic hydrocarbon radical with up to 8 carbon atoms, which is substituted by an aromatic nitrogen-containing heterocyclic radical with 5 or 6 ring-members and 1, 2 or 3 nitrogen atoms optionally substituted by halogen, alkoxy with up to 8 carbon atoms, alkyl with up to 8 carbon atoms, hydroxyl, carbalkoxy with up to 9 carbon atoms, carbamoyl, dialkylamino the alkyl moieties of which having up to 8 carbon atoms, cycloalkylamino, the cycloalkyl moiety having 3-10 carbon atoms, acetylamino, nitro, cyano, acetyl, alkylthio with up to 8 carbon atoms, alkylsulphinyl with up to 8 carbon atoms, alkylsulphonyl with up to 8 carbon atoms, sulphamoyl, phenyl, trifluoromethyl, phenoxy, acetoxy or methylenedioxy; or a pharmacologically acceptable salt thereof, exhibits immune stimulating activity.

N-Substituted aziridine-2-carboxylic acid derivatives and their

Aziridine-2-carboxylic acid derivatives of the formula ##STR1## wherein X is a carboxyl, nitrile, alkoxycarbonyl or carbamoyl group, and

N-Substituted aziridine-2-carboxylic acid derivatives and

N-Substituted aziridine-2-carboxylic acid derivatives for immuno

1-(N-Acyl-carbamoyl)-2-cyanoaziridines of the formula ##STR1## wherein X is oxygen or sulphur,

Immune-stimulating 1-(N-acylcarbamoyl)-2-cyanoaziridines

1-Acyl-2-cyanoaziridines of the formula ##STR1## wherein R is an acyl radical of a carboxylic, sulphonic, sulphinic, sulphenic, phosphonic or phosphoric acid, exhibit immune-stimulating and cancerostatic activities.

Immune-stimulating and cancerostatic 1-acyl-2-cyanoaziridines

New 3-nitropyrazole compounds of the formula: ##STR1## wherein R.sub.1 is lower alkyl;

3-Nitropyrazole compounds and anti-microbial compositions

New nitropyrazole compounds of the formula ##STR1## wherein R.sub.1 is alkyl or hydroxyalkyl

Nitropyrazole compounds and anti-microbial compositions

Cycloalkano-quinolone derivatives having anti-microbial activity characterized by the formula: ##STR1## wherein one of R.sub.1 and R.sub.2 designates hydrogen, halogen, nitro, amino, hydroxyl, acylamino, acyloxy, alkoxy or aryloxy and the other taken together with R.sub.3 forms an alkylene bridge containing 2 to 6 carbon atoms, X is hydrogen, lower alkyl, which may be substituted by a member of the group consisting of halogen, hydroxyl, acyloxy, alkoxy, aryloxy, aralkyloxy, mercapto, alkylmercapto, arylmercapto, arylsulfonyl, and alkylsulfonyl, or X is unsubstituted alkenyl including alkadienyl, or alkynyl and Y is hydroxyl, amino or lower alkoxy, and the pharmaceutically acceptable salts thereof.

Compositions using cycloalkano-quinolone derivatives and their method of

New cyclopenteno-quinolone derivatives of the formula ##STR1## wherein R is a saturated or unsaturated aliphatic hydrocarbyl, e.g., alkyl and alkenyl,

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Mannheim-Kafertal, undefined

Herbert Berger