Harvard College

The Brigham and Women's Hospital, Inc.

Children's Medical Center Corporation

The Cbr Institute for Biomedical Research, Inc.

Immune Disease Institute, Inc.

Herbert B Hechtman

Francis D Moore, Jr

Michael C Carroll

Richard E Justice

Gene A Grindlinger

Francis D Moore

Michael C Carrol

Jr Francis D Moore

The invention provides natural IgM antibody inhibitors that may be used to treat various inflammatory diseases or disorders.

Natural IGM antibodies and inhibitors thereof

Natural IgM antibodies and inhibitors thereof

A topical treatment for hemorrhoidal pain and for spasms of the sphincters and muscles located in the gastrointestinal (GI) tract is disclosed. The topical preparation includes the amino acid L-arginine in a pharmaceutically acceptable carrier substance, e.g., K-Y jelly, suppository, or ingestible formulation, and can be applied directly to the affected area. The topical preparation of the invention is effective for relieving the pain of hemorrhoids or for treating conditions resulting from spasms of sphincters of the GI tract including anal fissure, post operative rectal pain, hypertrophic pyloric stenosis, and pancreatitis, as well as conditions resulting from general spasm of the muscles of the GI tract.

Topical formulations and methods for treating hemorrhoidal pain and

Apparatus for measuring papillary muscle contractility when subjected to electrical stimulus while immersed in a test bathing liquid includes a test chamber for maintaining the liquid at a controlled temperature and having a membrane for diffusion of oxygen into the liquid, arms for mounting a muscle specimen in the liquid, electrodes for providing an electrical stimulus, and a system for measuring the contractile response of the muscle when subjected to electrical stimulus.

Apparatus for measuring papillary muscle contractility

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Chestnut Hill, MA, United States of America

Herbert B Hechtman