Seoul National University

Other

Snu Rdb Foundation

Industry-academic Cooperation Foundation, Kunsan National University

Heonjoong Kang

Jungyeob Ham

Jae-Young Ko

Hoo-Sang Hwang

Jaehwan Lee

Hong Ryul Ahn

WonHo Yih

Jung-Rae Rho

Young Hee Park

Hyung-Seop Kim

Jungwook Chin

The present invention relates to a compound as a peroxisome proliferator activated receptor (PPAR) activator and a hydrate, a solvate, a stereoisomer and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, a cosmetic composition, a muscle strengthening agent, a memory improving agent, a therapeutic agent for dementia and Parkinson's disease, a functional food and a feed composition containing the same.

Aryl compounds as PPAR ligands and their use

Provided are a production method for a potassium organotrifluoroborate compound having a hydroxyl group, and a novel potassium organotrifluoroborate compound having a hydroxyl group. The production method is advantageous in that a potassium organotrifluoroborate compound can be produced in a single reaction without recourse to a process of isolating and purifying an intermediate. The novel potassium organotrifluoroborate compound having a hydroxyl group is useful as a reactant which is widely used in the total synthesis of physiologically active natural products and diverse organic synthesis reactions including halogen substitution reactions, 1,2- and 1,4-addition reactions using a rhodium (Rh) catalyst, and Suzuki coupling reactions using a palladium (Pd) catalyst.

Potassium organotrifluoroborate derivative and a production method therefor

The present invention relates to a thiazole compound as a peroxisome proliferator activated receptor &#x3b4; (PPAR&#x3b4;) activator or pharmaceutically acceptable salts thereof, and a pharmaceutical composition, a functional cosmetic composition, a health food, health beverages, a food additive and animal feeds containing the same.

Thiazole compound (as PPAR&#x3b4;) ligand and pharmaceutical, cosmetic and health food comprised thereof

Provided is a method for massive culture ofwhich is a marine dinoflagellate causing diarrhetic shellfish poisoning, and methods for extracting, isolating and purifying the shellfish toxin pectenotoxin-2 from the cultured. Particularly,is cultured massively in massive culture apparatus comprising polycarbonate water bath having the bottom sinking down toward the center of the bottom; acryl tube (E) containing fluorescent lamp laid long in the center of the water bath; air supplying device (B) supplying the air to the sinking center of the bottom of the water bath; and air purifying device containing one or more devices selected from the group consisting of UV lamp (C) and carbon cartridge filter (D) purifying the air supplied by the said air supplying device.

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The present invention provides a process for preparing the compounds of formula (II) according to a single reaction, which is an important intermediate compound for synthesizing GW7647 (III) and GW9578 (IV) activating Peroxisome Proliferator Activated Receptor (hPPAR &#x3b1;).

Process for preparing the intermediate compounds for PPAR &#x3b1; ligands

The present invention provides a process for preparing thiazole derivatives of formula (XI), that activate the delta subtype of the human Peroxisome Proliferator Activated Receptor (hPPAR&#x3b4;), and also provides processes for compounds of formula (VI), (VII), (VIII) and (IX), intermediate compounds for preparation of the above compounds of formula (XI).

Growing community of inventors

Seongnam-si, South Korea

Heonjoong Kang