Waters Technologies Corporation

Micromass UK Limited

Henry Y Shion

Matthew A Lauber

Jennifer M Nguyen

Robert Birdsall

Ximo Zhang

Nilini Ranbaduge

Thomas H Walter

Ying-Qing Yu

Giorgis Isaac

Alan Millar

Gregory T Roman

David Jonathan Pugh

Melvin Blaze Muttikal Thomas

Yun Wang Alelyunas

Robert Lewis

Tim Riley

The present disclosure provides devices, systems, kits and methods useful for quantitation of biomolecules such as intact proteins and nucleic acids.

Devices and methods for the sensitive detection and quantitation of biomolecules

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 2.50% (v/v) difluoroacetic acid and less than about 100 ppb of any individual impurity, especially metal impurities. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules and small molecules

The present disclosure relates to the determination of analytes in a sample using chromatography. The present disclosure provides methods of separating an analyte from a sample. A mobile phase is flowed through a chromatography column. The mobile phase includes about 0.005% (v/v) to about 0.20% (v/v) difluoroacetic acid and less than about 100 ppb of any individual metal impurity. A sample including the analyte is injected into the mobile phase. The analyte is separated from the sample.

Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules

A mass spectrometer is disclosed comprising: a first vacuum chamber having an inlet aperture; a second vacuum chamber; a differential pumping aperture separating the vacuum chambers; and an ion guide arranged in the first vacuum chamber for guiding ions from the inlet aperture to and through the differential pumping aperture. The ion guide has a construction for handling high gas loads such that the spectrometer is able to maintain the gas pressure in the first vacuum chamber such that when ions are accelerated therethrough the ions collide with gas and fragment.

Mass spectrometer having fragmentation region

The present disclosure relates, in part, to MS apparatus, methods, and/or software, having improved selectivity, sensitivity, specificity, resolution, mass accuracy and dynamic range over conventional MS technologies. In particular, the technology relates to apparatus, methods, and/or software wherein a combination of in-source fragmentation, ion mobility separation, and/or time-aligned parallel (TAP) sample ion fragmentations are utilized in mass spectrometry for the analysis of samples.

Methods and apparatus for performing mass spectrometry

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Hopkinton, MA, United States of America

Henry Y Shion