Exelixis, Inc.

Henry William Beecroft Johnson

James William Leahy

Patrick C Kearney

Timothy Patrick Forsyth

Jeff Z Chen

Grace Mann

Tai Phat Huynh

Adam Galan

Brian Hugh Ridgway

Mohamed Ibrahim

Gary Lee Lewis

Hongwang Du

Peiwen Zhou

Matthew Sangyup Lee

Robin Tammie Noguchi

John M Nuss

Elena S Koltun

Naing N Aay

S David Brown

Craig Stacy Takeuchi

Sergey Epshteyn

Xian Shi

Byung Gyu Kim

Arlyn Arcalas

Wai Ki Vicky Chan

Michael Pack

Joon Won Jeong

Brian Kane

Lisa E Meyr

John Woolfrey

This disclosure relates to sphingosine-1-phosphate (S1P) receptor antagonists, compositions comprising the S1P receptor antagonists and methods for using and processes for making the S1P receptor antagonists. In particular, this disclosure relates to sphingosine-1-phosphate 1 (S1P1) receptor antagonists, compositions comprising the S1P1 receptor antagonist and methods for using the S1P1 receptor antagonist, such as in the treatment of cancer, and processes for making the S1P1 receptor antagonists.

Acetanilide sphingosine-1-phosphate receptor antagonists

This invention relates to certain pyrimidine derivative inhibitors of JAK-2, having Formula (I): wherein D, E, L, Z, R, R, R, and n1 are as defined in the specification, pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof.

4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as JAK-2 modulators and methods of use

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.

JAK-2 modulators and methods of use

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San Bruno, CA, United States of America

Henry William Beecroft Johnson