Riptide Bioscience, Inc.

Other

National Institutes of Health, a Component of the US Dept. of Health & Human Services

Henry Wilfred Lopez

Jesse M Jaynes

George R Martin

Clayton Yates

Charles Garvin

Kathryn Wynne Woodburn

L Edward Clemens

Adam Loren Freund

Lazaro Balseiro

Udo Rudloff

Christa Lafayette

Charles E Garvin

Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent antimicrobial activity, broad-spectrum antimicrobial activity, and/or the ability to kill otherwise antibiotic-resistant microbes, or microbes protected by biofilms.

Antimicrobial peptides and methods of using the same

The present disclosure provides novel peptides that having immunomodulatory activities in vitro and in vivo. The peptides can include a particular striapathic region of alternating hydrophilic and hydrophobic modules that can adopt an amphipathic conformation under physiological conditions. This disclosure provides peptides that can specifically bind to key functional regions on one or more signaling proteins, particularly pro-inflammatory cytokines, macrophage inhibition proteins, and histone regulation proteins. This disclosure includes peptides that are sufficiently stable in the circulation to allow for intravenous administration. Pharmaceutical compositions including the subject peptides are also provided. The subject peptides find use in methods of modulating macrophage activity. In some cases, the peptide is a CD206-binding agent. Also provided are methods of treating a subject for a condition associated with chronic inflammation using the peptides and compositions of this disclosure.

Peptides having immunomodulatory properties

The methods of the present invention are based upon the gathering of information from various sources about animals. The information is based upon laboratory testing, genetic analysis and observations by owners and/or trainers about various traits that can be readily observed. Based upon this collection of information, one method generates Performance Index which scores or ranks an animal in terms of how well an animal might function for the intended purpose. Other methods include the ability to selection an optimum breeding pair from one or more stallions and/or one or more mares that would likely produce an offspring with the desired traits.

Using a breed matching database and genetic markers for color, curiosity, speed and gait to breed offspring with predetermined traits

Aspects of the present invention relate to peptides having anti-inflammatory activity, compositions containing one or more of the peptides, and use of the peptides to treat conditions associated with excessive inflammation in animals, particularly humans and other mammals.

Peptides having anti-inflammatory properties

Antimicrobial peptides and methods of use thereof

Methods for treating a subject for pancreatic cancer via administration of small anti-inflammatory peptides are disclosed. The peptides may be administered in conjunction with another therapeutic agent, such as a chemotherapeutic agent, or therapeutic regimen. In some cases, the anti-inflammatory peptide that finds use in the subject methods has the amino acid sequence Lys-Phe-Arg-Lys-Ala-Phe-Lys-Arg-Phe-Phe (SEQ ID NO:1) or a multimer, derivative, or variant thereof.

Peptide-based methods for treating pancreatic cancer

An apparatus for lifting a panel to a ceiling has a post having an upper end and a lower end, a spring in the post between the upper and lower ends for at least limited longitudinal compression of the post against a spring force, and a foot pivoted on the lower end about a foot axis transverse to the longitudinal axis. A handle is pivoted on the post between its ends about a handle axis generally parallel to the foot axis and a panel-engaging support bar is pivoted on the upper end of the post about a bar-pivot axis generally parallel to the foot and handle axes, extends perpendicular to this bar-pivot axis, and has one end provided with an outwardly directed cleat. Thus this bar can be engaged under the panel with the cleat against an edge of the panel. At least one bar spring is operatively engaged between the bar and the post for biasing the bar into a position extending perpendicular to the post.

Growing community of inventors

Napa, CA, United States of America

Henry Wilfred Lopez