Other

University of California

Northrop Grumman Systems Corporation

Telefonaktiebolaget Lm Ericsson (publ)

Celgene Corporation

Baker Hughes Corporation

Trw Limited

Henry Ping Chang

Andrew Lee Roberts

Steven Szu-Cherng Kuo

Imants Eglitis

James David Ingram

David Wassarman

Felix Karim

Marc Therrien

Gerry Rubin

Ellen Filvaroff

Antonia Lopez-Girona

Shailaja Kasibhatla

Rama Krishna Narla

Michael Pourdehnad

Tonia J Buchholz

Maria Soraya Carrancio Anton

Anjan Thakurta

William Edward Pierceall

Kiran Patel

Chirag Parekh

George Lapiotis

Franklin J Chang

Adithi Mohan

Thomas McClain Scott

James Joseph Freeman

Michael Forsberg

Mike Allen Swatek

Steve James Coulston

Nicholas L Bayard

Provided herein are methods of using (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, in combination with a second active agent for treating, preventing or managing hematological malignancies. The second active agent is one or more of an HDAC inhibitor, a BCL2 inhibitor, a BTK inhibitor, an mTOR inhibitor, a PI3K inhibitor, a PKCβ inhibitor, a SYK inhibitor, a JAK2 inhibitor, an Aurora kinase inhibitor, an EZH2 inhibitor, a BET inhibitor, a hypomethylating agent, a DOT1L inhibitor, a HAT inhibitor, a WDR5 inhibitor, a DNMT1 inhibitor, an LSD-1 inhibitor, a G9A inhibitor, a PRMT5 inhibitor, a BRD inhibitor, a SUV420H1/H2 inhibitor, a CARM1 inhibitor, a PLK1 inhibitor, an NEK2 inhibitor, an MEK inhibitor, a PHF19 inhibitor, a PIM inhibitor, an IGF-1R inhibitor, an XPO1 inhibitor, a BIRC5 inhibitor, or a chemotherapy.

Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use

Provided herein are methods of using (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, in combination with a second active agent for treating, preventing or managing hematological malignancies. The second active agent is one or more of an HDAC inhibitor, a BCL2 inhibitor, a BTK inhibitor, an mTOR inhibitor, a PI3K inhibitor, a PKC&#x3b2; inhibitor, a SYK inhibitor, a JAK2 inhibitor, an Aurora kinase inhibitor, an EZH2 inhibitor, a BET inhibitor, a hypomethylating agent, a DOT1L inhibitor, a HAT inhibitor, a WDR5 inhibitor, a DNMT1 inhibitor, an LSD-1 inhibitor, a G9A inhibitor, a PRMT5 inhibitor, a BRD inhibitor, a SUV420H1/H2 inhibitor, a CARM1 inhibitor, a PLK1 inhibitor, an NEK2 inhibitor, an MEK inhibitor, a PHF19 inhibitor, a PIM inhibitor, an IGF-1R inhibitor, an XPO1 inhibitor, a BIRC5 inhibitor, or a chemotherapy.

A system and method for dynamically (re)configuring a service network based on profile information obtained from a Big Data Analytics platform. Received dynamic situation profiles relative to network states, subscriber states, etc. may be compared against corresponding characteristic situation profiles. If there is a similarity, a dynamic design change action may be effectuated for changing configuration of at least a part of the service network, e.g., a service chaining mechanism, operating to service user data flows of the subscribers.

Analytics-driven dynamic network design and configuration

A method of managing data obtained in a borehole is provided. The method includes monitoring a characteristic with at least one sensor and obtaining raw data therefrom; indexing the raw data with the at least one sensor; recording the indexed data with the at least one sensor; forming a data packet with the at least one sensor, the data packet including at least a portion of the indexed data and index information; and transmitting the data packet in a predetermined segment of a communication protocol.

Communications protocol for downhole data collection

A skin treatment device includes a handle and a tip, having a skin applying surface, detachably coupled to the handle. A fluid delivery structure is formed at skin applying surface and has an aperture and a vacuum entry port. A fluid detouring path is defined between the aperture and the vacuum entry port for prolonging a traveling path of fluid from the aperture and the vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip.

Skin treatment device

An apparatus for transdermal fluid delivery includes a handle and a tip, having a skin applying surface, being driven to move by a driving unit. A fluid delivery structure has an aperture formed at the skin applying surface and a vacuum entry port. An abrading structure, an electrode structure, and a micro-needling structure are selectively provided at the skin applying surface with the fluid delivery structure to provide multiple functions of the tip. A flow of fluid is delivered onto the skin applying surface through the fluid delivery structure to interact with the abrading elements and the electrodes before the fluid is returned and collected, so that three different skin treatments of abrasive peeling, electrical stimulation, and liquid infusion are achieved in one single structure for improving a skin structure.

Apparatus and method for transdermal fluid delivery

A skin treatment apparatus includes a handle body, a driving unit received in a receiving cavity of the handle body, a treatment head unit, and an inlet arrangement. The treatment head unit includes a supporting member provided at the front end portion of the handle body, a treatment cap detachably attached on the supporting member, a treatment shaft rotatably connected to the driving unit and extended from the driving unit into a treatment cavity, and an abrasion head integrally formed at a free end of the treatment shaft in such a manner that when the treatment shaft is driven to rotate, the abrasion head is also driven to rotate with respect to the handle body. The inlet arrangement is formed at the supporting member of the treatment head unit for providing a predetermined amount of skin treatment fluid in the treatment cavity.

Skin treatment apparatus

A method for making a feed structure for an antenna may include providing a polarizer body having a polarizer sidewall extending longitudinally between spaced apart ends. A portion of the polarizer sidewall is deformed to provide at least one polarizing structure that extends radially inwardly along an interior of the polarizer sidewall relative to adjacent portions of the polarizer sidewall. The method thus can be utilized to produce an antenna structure.

Method for making an antenna structure

A polarizer for an antenna and antenna structures are disclosed. According to one aspect a polarizer includes a generally cylindrical sidewall portion extending between spaced apart end portions. At least one polarizing structure extends substantially continuously along an interior of the sidewall portion and extends radially inwardly relative to the sidewall portion according to a first radius in a longitudinal direction and a second radius in a transverse direction. The polarizer can be implemented as part of an antenna structure, which further can be integrated with a transition stage and/or a horn.

Feed structure and antenna structures incorporating such feed structures

A tissue removal pen includes a pen body having a working end and a handle portion, and an abrasion unit, which is mounted on the pen body, including an abrasion head extended outwardly from the working end of the pen body for removing cells from a treating skin surface of a user. A collecting unit includes a collecting conduit, which is mounted on the pen body, having a discharging end and an intake end extended toward the working end, and a collecting head replaceably mounted to the intake end of the collecting conduit and extended from the working end of the pen body to a position that adjacent to the abrasion head of the abrasion unit. A vacuuming source is connected to the discharging end of the collecting conduit to provide a reduced pressure within the collecting head for collecting cells removed from the treating skin surface.

Tissue removal pen

An apparatus ( ) for connection with a vehicle portion ( ) comprises a grab handle ( ) and a grab handle hinge ( ). The grab handle hinge ( ) supports the grab handle ( ) for pivotal movement relative to the vehicle portion ( ) between a grab handle stored position adjacent the vehicle portion ( ) and a grab handle operative position spaced apart from the vehicle portion ( ). A cap ( ) blocks visibility of part of the grab handle hinge ( ) from the vehicle occupant compartment when the grab handle ( ) is in the grab handle stored position. A cap hinge ( ) supports the cap ( ) for pivotal movement between a cap stored position covering the part of the grab handle hinge ( ) and a cap operative position spaced apart from the vehicle portion ( ) and from the grab handle hinge ( ). The cap ( ) has a portion ( ) adapted to support a garment when the cap ( ) is in the cap operative position.

Retractable grab handle and coat hook

A peeling apparatus for removing surface portions of human tissue by superficial abrasion caused by a stream of a mixture of air with at least one granular abrasive substance striking on the surface portion of the human tissue to be removed, wherein the peeling apparatus includes a purging arrangement includes a first and a second switch. The first switch includes a control switch valve connected at the first air dust, for regulating the compressed air flowing from the air filtering outlet member of the collection reservoir to the suction pump normally, and being selectively switched to cut off the connection between collection reservoir and the air inlet of the suction pump while instantaneously connecting the air outlet of the suction pump to the air filtering outlet member instead, so as to deliver the air output from the air outlet of the suction pump reversely to the air filtering outlet member for purging a clogged condition thereof The second switch is adapted for normally ensuring the air outlet of the suction pump connected to outside and selectively switching to instantaneously connect the air outlet of the suction pump to the fresh substance outlet member of the abrasive substance supply so as to deliver the air output from the air outlet of the suction pump reversely to the fresh substance outlet member for purging a clogged condition thereof.

Peeling apparatus for removing surface portions of human tissue with purging arrangement

The present invention provides a facial steamer machine with detachable function units, in which all kinds of skin care appliance are independently constructed into a plurality of function units which are adapted to incorporate with the facial steamer machine, so that the user may selectively combine several function units to detachably connect and equip with the facial steamer machine to form a single skin care system. The facial steamer machine of the present invention can also reduce the overall manufacturing cost by utilizing some common components such as the movable stand and the power wiring arrangement. Therefore, the present invention occupies less storage space and operating space. Moreover, it is easier to maintain too.

Growing community of inventors

San Marino, CA, United States of America

Henry Ping Chang