Immulogic Pharmaceutical Corporation

Merck Patent Gmbh

Immulogic Pharamaceutical Corp.

Henry M Franzen

Mei-chang Kuo

Bruce L Rogers

Julia L Greenstein

Richard D Garman

Xian Chen

Sean Evans

Ze'ev Shaked

Ze&prime;ev Shaked

The present invention provides isolated peptides of the major protein allergens of the genus. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

T cell epitopes of the major allergens from dermatophagoides (house dust mite)

The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprises at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

T cell epitopes of the major allergens from Dermatophagoides (house dust

T cell epitopes of the major allergens from dermatophagoides (house dust

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Watertown, MA, United States of America

Henry M Franzen