American Cyanamid Company

Henry L Strong

David A Cortes

Zareen Ahmed

Nicholas A Cortese, Jr

Robert S Marmor

The invention is herbicide 3-substituted quinoline intermediates and a method for the synthesis of the herbicide intermediates 3-alkoxymethyl substituted quinolines.

Substituted quinoline herbicide intermediates and process

The invention is a process for preparing substituted 8-hydroxyquinolines from substituted 8-chloroquinolines.

Coversion of substituted 8-chloroquinolines to substituted

There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pylidinedicarboxylic acids.

5,6-disubstituted-3-pyridylmethyl ammonium halide compounds useful for

There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine. There is also provided a process for the manufacture of 3-alkoxymethylquinolines from 2-alkoxymethylacrolein.

Process for the manufacture of 2-alkoxymethylacrolein

There are provided crystalline substituted-2,3-dicarboxypyridinium nitrate salts, the preparation thereof and the use thereof in the isolation and purification of important substituted pyridinedicarboxylic acid herbicide intermediates.

Preparation of substituted-2,3-dicarboxypyridinium nitrates

An improved manufacturing procedure for the preparation and isolation of cyclopropylnitrile is provided. 4-Halobutyronitrile is reacted with an alkali metal base in the presence of an aprotic polar solvent, an inorganic salt and a catalytic amount of water at an elevated temperature. The reaction product cyclopropylnitrile is isolated by azeotropic distillation.

Process for the manufacture of cyclopropylnitrile

There are provided 5,6-disubstituted-3-pyridylmethyl ammonium halide compounds, a method for the preparation thereof and the use thereof for the preparation of 5-(substituted methyl)-2,3-pyridinedicarboxylic acids.

There is provided an improved process for the preparation of substituted and unsubstituted 2,3-pyridinedicarboxylic acids in significantly enhanced yield by the nitric acid oxidation of the appropriately substituted quinoline precursor in the presence of a catalytic amount of Manganese.

Method for the preparation of 2,3-pyridine-dicarboxylic acids and

Substituted-2,3-dicarboxypyridinium nitrates

There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine.

Proccess for the manufacture of 2-alkoxymethylacrolein

There is provided a process for the preparation of a substituted or unsubstituted 2,3-pyridine or quinolinedicarboxylic acid by hydrolysis of a substituted or unsubstituted 2,3-pyridine or quinolinedicarboxylic acid diester with an acid having an ionization constant pK.sub.a of less than 3.0 followed by isolation of the product as the free acid or an acid salt.

Method for the preparation of substituted and unsubstituted 2,3-pyridine

There is provided an oxidation process using potassium permanganate as oxidizing agent, for the preparation of certain animal growth promoters, namely, N-(4,5,6,7-tetrahydro-7-oxobenzo[b]thien-4-yl)amides, 4,5,6,7-tetrahydro-7-oxobenzo[b]-thien-4-ylureas, N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)amides and 1,2,3,4-tetrahydro-4-oxo-1-naphthylureas, said process affording such compounds in markedly improved yields, and being readily suitable for scale-up.

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Somerset, NJ, United States of America

Henry L Strong