E.i. Dupont De Nemours and Company

Actamax Surgical Materials, LLC

Isp Investments Inc.

Actamax Surgerical Materials, LLC

Henry Keith Chenault

Robert DiCosimo

Samuel David Arthur

Anna Panova

Garret D Figuly

Mark Allen Andrews

Ramabhadra Ratnagiri

Petros Gebreselassie

Yevgeniy Turovskiy

Karen Winkowski

Disclosed herein is an oral hygiene composition comprising a styrene-maleic acid copolymer or terpolymer or salt thereof, wherein the copolymer or terpolymer or salt thereof has a polydispersity ranging from about 2 to about 14 and a minimum biofilm inhibitory concentration (MBIC) ranging from 0.001 ppm to 1000 ppm to reduce deposition of an oral biofilm on teeth or soft tissue. Also disclosed are processes for preparing a styrene-maleic acid copolymer or terpolymer or salt thereof.

Oral hygiene compositions for preventing the formation of oral biofilms and process for preparing the same

A tissue adhesives and sealant formed by reacting a polyglycerol aldehyde with a water-dispersible, multi-arm amine is described. The tissue adhesive and sealant may be useful for medical and veterinary applications, including, but not limited to, wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and to prevent post-surgical adhesions.

Tissue adhesive and sealant comprising polyglycerol aldehyde

Polyoxymethylene compositions with polyoxymethylene polymers polymer/polyol additives having a core-link-arm structure. Upon molding, these compositions exhibit stable melt viscosity and simultaneous improvement in notched Izod impact strength and/or decreased relative apparent capillary melt viscosity, and/or increased elongation at break, relative to polyoxymethylene compositions lacking such core-link-arm structure additives.

Polyoxymethylene compositions with branched polymers

Processes for improving melt flow properties of molten compositions with polyoxymethylene polymers and polymer/polyol additives having a certain core-link-arm structure, which include: obtaining melt viscosity stability while improving notched Izod, decreasing relative apparent capillary melt viscosity, and increasing elongation at break relative to molten compositions of polyoxymethylene polymers without the polymer/polyol additives.

Obtaining melt viscosity stability of polyoxymethylene compositions

Novel polyglycerol aldehyde polymers are described. The polymers comprise glycerol monomers connected by ether linkages and have 3 to about 170 aldehyde groups per molecule. The polyglycerol aldehydes may be reacted with various amine-containing polymers to form hydrogel tissue adhesives and sealants that may be useful for medical applications such as wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, tissue repair, preventing leakage of fluids such as blood, bile, gastrointestinal fluid and cerebrospinal fluid, ophthalmic procedures, drug delivery, and preventing post-surgical adhesions.

Polyglycerol aldehydes

Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions.

Crosslinked polymers containing biomass derived materials

Processes for preparing crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels.

Preparation of crosslinked polymers containing biomass derived materials

Tissue adhesives formed by crosslinking albumin and/or gelatin with certain polyamines and/or polycarboxylates using a water-soluble carbodiimide are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; anti-adhesive applications; and as a bulking agent to treat urinary incontinence are described.

Protein-based polymer tissue adhesives for medical use

An embodiment of the invention is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether amine with a bifunctional crosslinker of the formula: X&#x2014;R&#x2014;X. Another embodiment is a water soluble chain-extended polyamine product made by a process comprising reacting a multi-arm polyether having at least three arms and three electrophilic endgroups with a primary diamine crosslinker of the formula: NH&#x2014;R&#x2014;NH, followed by treating of the chain-extended product so as to convert the remaining electrophilic endgroups to amine endgroups. Crosslinking of the chain-extended polyamine products with an oxidized polysaccharide provides useful tissue adhesives with modified elasticity, that provides greater compliance to underlying tissue, and improved stability in aqueous environments.

Tissue adhesives with modified elasticity

A method for preparing multi-arm poly(ethylene glycol) (PEG) chlorides from multi-arm PEG polyols is described. The method comprises a process, wherein the multi-arm PEG polyol is reacted with thionyl chloride to form the multi-arm PEG chloride.

Method for preparing multi-arm poly(ethylene glycol) chlorides

A process is provided to improve the specific activity of an enzyme catalyst having nitrilase activity when converting glycolonitrile to glycolic acid under aqueous reaction conditions. Inclusion of an effective amount of at least one amine protectant improves the specific activity and catalytic productivity of the enzyme catalyst.

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Hockessin, DE, United States of America

Henry Keith Chenault