Merck + Co., Inc.

Other

Henry Joshua

Gerald E Stokker

Otto D Hensens

Ta J Lee

Jerrold M Liesch

Kenneth E Wilson

Guy H Harris

George E Albers-Schonberg

Maria B Lopez

Michael S Schwartz

Douglas K Miller

Arthur A Patchett

Bruce E Witzel

Deborah L Zink

Nathaniel Grier

Richard A Dybas

Janet C Onishi

Robert E Schwartz

George M Garrity

Raymond F White

Dennis M Schmatz

Robert A Giacobbe

Elbert E Harris

Sagrario M Del Val

Isabel Martin

Michael D Greenspan

Walter Rozdilsky

James A Milligan

Maria T Matas

Sharon J Sadowski

An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

Cholesterol lowering compounds

A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.

An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.

Antibiotic cyclopeptide fermentation product

Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

Novel HMG-CoA synthase inhibitors

Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.

3-keto HMG-CoA reductase inhibitors

3-keto HMG-COA reductase inhibitors

A high pressure liquid chromatography jacket includes a rectangular, fluid-tight enclosure which has a removable cover on which a pair of tubing seal fittings are mounted. The fittings form a fluid-tight seal around the inlet and discharge tubes of a chromatographic column which is mounted in the enclosure. The enclosure is connected to a source of temperature controlled fluid which circulates through the enclosure and controls the temperature of the chromatographic column. In an alternative embodiment of the invention, a valve is provided which allows sample materials being loaded to enter a sample storage loop, which is exposed to the temperature controlled fluid. The sample, whose temperature has been controlled by the temperature controlled fluid, is then injected into a chromatographic column under high pressure.

High pressure liquid chromatography column jacket

6-Hydroxy-2-(2-hydroxy-4-methoxyphenyl)benzofuran derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapuetic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit

Medicarpin derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.

Medicarpin derivatives and analogs

An all-TEFLON filter-degasser for removing solids and gases from a solvent. The filter-degasser has a filtering portion, a vacuum application portion downstream of the filtering portion, and a solvent bottle connecting portion. The vacuum application portion includes an externally tapered male member, and the solvent bottle connecting portion includes an internally identically tapered female member. The male member can be inserted into and withdrawn from the female member without requiring any relative rotation therebetween, so that the filter-degasser can be connected hermetically airtight to the solvent bottle likewise without any rotation being required therebetween. This abstract is not to be taken either as a complete exposition or as a limitation of the present invention, however, the full nature and extent of the invention being discernible only by reference to and from the entire disclosure.

Filter-degasser

Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.

Hypocholesteremic fermentation products and process of preparation

4-Amino- and 2,4-diaminopyrimidines with a quaternized ring nitrogen and an oxygen bearing substituent such as hydroxyalkyl, alkoxyalkyl, or alkanoyl on one of the exo- or endocyclic nitrogens and a C.sub.6-18 alkyl on another, are highly active antimicrobial agents with a relatively low acute mammalian toxicity.

Antimicrobial aminopyrimidinium salts

Hypocholesteremic fermentation products and products of preparation

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Staten Island, NY, United States of America

Henry Joshua