Schering Corporation

Air Products and Chemicals, Inc.

Henry J Doran

Pat M O'Neill

Donal J Coveney

Augustine I Dalton, Jr

Robert Parry Williams

Patrick O'Neill

Brian Keaveny

Robert D Murray

Process of synthesis of a tricyclic ketone intermediate

Disclosed is a process for preparing a compound having the formula:

Process for preparing tricyclic compounds having antihistaminic activity

Process for preparing a key intermediate, 2-methyl-3-trifluoromethylaniline (MTA) of Flunixin, as well as novel intermediates thereof are described.

Process for preparing flunixin and intermediates thereof

Process for preparing Flunixin and intermediates thereof

A process for destructively scrubbing methyl chloride gas comprising contacting the gas with a scrubbing solution comprising ethanolamine is described.

Method for the destructive scrubbing of methyl chloride gas

Described is a process for preparing 2-phenyl-1,3-propanediol by converting the 2-nitro-2-phenyl-1,3-propanediol to a nitro-dioxane of the formula ##STR1## wherein the groups R are both C.sub.1 -C.sub.6 alkyl or together comprise a C.sub.5 -C.sub.6 cycloalkyl group, or wherein one R group is H and the other is phenyl; hydrogenolysis of the nitro-dioxane to give a dioxane of the formula ##STR2## wherein R is as defined above; and hydrolyzing the dioxane to form 2-phenyl-1,3-propanediol.

Process for preparing 2-phenyl-1,3-propanediol

Primary and secondary unsaturated alcohols are converted to their corresponding aldehydes and/or carboxylic acids and ketones respectively with alkali metal (per) halate, preferably sodium periodate, in the presence of ruthenium catalyst. The process is particularly useful in the oxidation of chrysanthemyl alcohol. Any unconverted intermediate aldehyde formed may be converted to the acid by recycling or by a separate oxidation step.

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Bray, Ireland

Henry J Doran