Rorer Pharmaceutical Corporation

William H. Rorer, Inc.

Rhone-poulenc Rorer Pharmaceuticals Inc.

Other

Rorer Pharmaceutical Corporaton

Henry F Campbell

Donald E Kuhla

William L Studt

Robert A Galemmo, Jr

William C Faith

George H Douglas

Bruce F Molino

Fu-chi Huang

Raymond D Youssefyeh

Stuart A Dodson

Alfred P Spada

John Yelnosky

Jeffrey C Pelletier

Kent W Neuenschwander

Scott I Klein

Norman J Santora

Raymond Youssefyeh

Thomas Tucker

Keith S Learn

Thomas H Scholz

Pamela J Durham

Thomas Joseph Tucker

James Barnes

Matthew R Powers

Fu-Chih Huang

Bernard J Burns

John E Airey

Dennis L Decktor

Fu-Chich Huang

Norman F Santora

Paul R Darkes

Donald E Kubla

Leo R Fitzpatrick

This invention is directed to certain dibenzofurancarboxamides and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinctic activity void of any significant D.sub.2 receptor binding properties. This invention also describes novel processes necessary for their preparation.

Pharmaceutically useful dibenzofurancarboxamides of specific

A building construction for industrial, commercial or similar buildings comprising at least one wall made of a plurality of prefabricated panels, each of which comprises to transversely spaced trusses to which spaced sheets are fastened. The panels are assembled on a base wall in side-by-side relationship with the transversely outermost truss of each panel closely adjacent and preferably in abutment with the adjacent outwardly positioned truss of the adjacent panel. A load plate is provided at each of the areas of juncture between panels. Joists, trusses or prefabricated roof panels extend horizontally from the load plates to provide a ceiling or roof structure. The panels comprise a pair of abutting trusses along each side edge of each panel. In another form, each panel includes a pair of trusses adjacent the transverse mid-point which are closely adjacent and preferably in abutting relationship with a load bearing plate at the transverse midpoint.

Prefabricated load bearing panel

Quinolinyl styryl compounds and their use as pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and anti-allergic properties.

Quinoline derivatives as antagonists of leukotriene D4

Quinolinyl-benzopyran derivatives as antagonists of leukotriene D4

This invention relates to a series of bicyclic benzomonoazacyclic carboxamide compounds of the general formula: ##STR1## Where Z is tertiary amine, which are useful for the method of treating patients suffering from gastrointestinal disorders, and of pharmaceutical composition including an effective 5HT3 - antagonists amount of said compounds therein.

Substituted saturated and unsaturated indole quinoline and benzazepine

Quinoline derivatives and their use as antagonists of leukotriene D.sub.4

Quinoline derivatives as antagonists of leukotriene D.sub.4

This invention relates to substituted pyridooxazinone and naphtheridone pyridones which are useful as cardiotonic agents for the treatment of congestive heart failure, to methods for increasing cardiac contractility using said compounds, and pharmaceutical compositions including the same.

Naphtheridinone- and pyridooxazinone-pyridone compounds, cardiotonic

Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure: ##STR1## where A is ##STR2## R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.9, and R.sub.10 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms; and n is 0 or 1.

Compounds having cardiotonic activity

This invention relates to certain quinolinyl-chromone compounds and their use as valuable pharmaceutical agents, particularly as lipoxygenase inhibitors and/or leukotriene antagonists possessing anti-inflammatory and anti-allergic properties.

Quinolinyl-chromone derivatives and use for treatment of hypersensitive

This invention is directed to certain dibenzofurancarboxamides and their use as 5HT.sub.3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D.sub.2 receptor binding properties. This invention also describes novel processes necessary for their preparation.

Hexahydrodibenzofuran carboxylic acid derivatives

This invention relates to pyridyl-pyrazolinone compounds of the formula ##STR1## uses of said compounds as cardiotonic agents including methods for increasing cardia contractility and the treatment of congestive heart failure, pharmaceutical compositions including the same and methods for the preparation thereof.

Pyridyl-pyridazinone and pyridyl-pyrazolinone compounds and their use in

This invention relates to benzoxazine and benzoxazepine carboxamide compounds which exhibit 5-HT.sub.3 antagonist properties including CNS, anti-emetic and gastric prokinetic activity and which are void of any significant D.sub.2 receptor binding affinity. This invention also relates to pharmaceutical compositions and methods for the treatment of gastrointestinal and mental disorders using said compounds.

Benzoxazine and benzoxazepine carboxamide 5-HT.sub.3 antagonists

This invention relates to heteroazabenzo-bicyclic substituted carboxamide compounds of the formula: ##STR1## where W is O, S or NR.sub.5 and

Heteroazabenzobicyclic carboxamide 5-HT.sub.3 antagonists

Growing community of inventors

Lansdale, PA, United States of America

Henry F Campbell