Permeable Technologies, Inc.

Henry D Coleman

Waifong Liew Anton

Harry J Spinelli

Lester Weintraub

Mohammed I Ali

Leonard Seidner

Paul White

The present invention relates to novel preformed silicone-containing acrylic copolymers including silicone-containing acrylic star polymers, graft copolymers and macromonomers. Described are linear diblock macromomomers, graft copolymers and star polymers comprising a substantially hydrophilic block or block and a substantially hydrophobic, permeable block or block, said hydrophilic block preferably comprising at least about 25% by weight of a hydrophilic acrylic-type monomer and said hydrophobic, permeable block comprising at least about 50% by weight of at least one or more polysiloxanylalkylesters of an alpha, beta unsaturated acid.

Silicone-containing acrylic star polymers, block copolymers and

The present invention relates to novel copolymers and contact lenses made from these copolymers comprising preformed silicone-containing acrylic star polymers, graft copolymers and macromonomers, preparation of these contact lenses and a therapeutic method for treating patients with visual impairment. Described is a composition comprising at least about 10% by weight of a preformed silicone-containing acrylic copolymer and no more than about 90% by weight of a matrix formed from the random polymerization of a mixture of monomers. The mixture of monomers comprises at least one hydrophilic monomer and at least about 5% by weight of a polysiloxanylalkylester of an alpha, beta unsaturated acid and optionally, monomers selected from the group consisting of esters of alpha, beta-unsaturated acids and crosslinking monomers. The preformed silicone-containing acrylic copolymer is preferably copolymerized throughout the matrix. The final compositions are hydrated to a final water content of at least about 10% by weight.

Silicone-containing polymers, compositions and improved oxygen permeable

The present invention relates to novel copolymers and contact lenses made from these copolymers comprising preformed silicone-containing acrylic star polymers, graft copolymers and macromonomers, preparation of these contact lenses and a therapeutic method for treating patients with visual impairment. Described is a composition comprising at least about 10% by weight of a preformed silicone-containing acrylic copolymer and no more than about 90% by weight of a matrix formed from the random polymerization of a mixture of monomers. The mixture of monomers comprises at least one hydrophilic monomer and optionally, monomers selected from the group consisting of silicone acrylates, esters of alpha, beta-unsaturated acids and crosslinking monomers. The preformed silicone-containing acrylic copolymer is preferably copolymerized throughout the matrix. The final compositions are hydrated to a final water content of at least about 10% by weight.

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Brooklyn, NY, United States of America

Henry D Coleman