Applied Analytical Industries, Inc.

Smithkline Corporation

Formulations Development Labs

Henry C Caldwell

Bernard Loev

Moo K Park

Ashok J Desai

James Swarbrick

Dale W Blackburn

Martin W Beasley

Frank C Greaves

Andrew W Suddith

Moo W Park

Method for preparing low dose pharmaceutical products

The present invention provides a pharmaceutical composition for the oral administration of an H.sub.2 -antagonist. The composition includes an H.sub.2 -antagonist and a silicate taste-masking agent capable of forming an adsorbate complex with the H.sub.2 -antagonist wherein the complex exhibits a non-bitter taste. The complex inhibits the release of the H.sub.2 -antagonist in the oral cavity.

Oral compositions of H2-antagonists

Pharmaceutically elegant oral compositions of non-steroidal anti-inflammatory drugs or their salts are prepared by adding selected dispersing agents such as a polyvinylpyrrolidone, hydroxypropyl-methylcellulose or hydroxypropylcellulose to the NSAIDs in a medium of polyol-glycol-alcohol. The compositions offer the formation of finely dispersed active ingredients upon dispersion in gastric juice.

Oral liquid compositions of non-steroidal anti-inflammatory drugs

A one phase, liquid composition for oral administration comprises a NSAID such as an anthranilic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as known to those skilled in the art. Other pharmaceutical additives may be optionally added. An additional stipulation is that ethanol or other monohydric alcohol solvents should not be present.

Liquid oral pharmaceutical compositions of non-steroidal

A one phase, liquid composition for oral administration comprises a NSAID such as an indoleacetic acid derivative or a pyrroleacetic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as known to those skilled in the art. Other pharmaceutical additives may be optionally added. An additional stipulation is that ethanol or other monohydric alcohol solvents should not be present.

A pharmaceutically elegant, one phase, liquid composition for oral administration comprises a NSAID such as ibuprofen plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as known to those skilled in the art. Other pharmaceutical additives may be optionally added. An additional stipulation is that ethanol or other monohydric alcohol solvents should not be present.

The compounds are alkanesulfonic acid salts of decinine. These salts are water soluble. Decinine and the salts thereof have glucocorticoid-like water diuretic and anti-inflammatory activity.

Alkanesulfonic acid salts of decinine

Pharmaceutical compositions and methods of inhibiting gastric acid secretion by administering N-aminomethyl heterocyclic thioacetamide compounds.

Pharmaceutical compositions and methods of inhibiting gastric acid

N-Aminomethyl heterocyclic thioacetamide compounds are prepared by reacting a heterocyclic thioacetamide with formaldehyde and an amine. The products inhibit gastric acid secretion.

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Ambler, PA, United States of America

Henry C Caldwell