Bayer Healthcare LLC

Ascensia Diabetes Care Holdings Ag

Henry C Arndt

Huan-Ping Wu

Jing Lin

Fu Hsiung Tsai

Nicole D Ellis

Karen L Marfurt

Jiangfeng Fei

Steven Fowler

A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.

Method of using an electrochemical test sensor

A method of forming a 3-phenylimino-3H-phenothiazine or a 3-phenylimino-3H-phenoxazine mediator includes providing a first reactant including phenothiazine or phenoxazine, providing a first solvent, providing a second reactant and providing a second solvent. The first reactant, first solvent, second reactant and second solvent are combined to form a reactants solution. Sodium persulfate is added to the reactants solution to couple the first and second reactants resulting in a reaction solution including the 3-phenylimino-3H-phenothiazine or the 3-phenylimino-3H-phenoxazine mediator.

Mediator for test sensor

The present invention is directed to phenothiazine-based macromonomer compounds and methods of making the same. 

Radically polymerizable phenothiazine macromonomer for use in the coating of medical devices

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Elkhart, IN, United States of America

Henry C Arndt