Bionano Genomics, Inc.

Henry B Sadowski

Han Cao

Alex R Hastie

Michael G Saghbini

Goran Pljevaljcic

Ming H Xiao

Methods for single-molecule preparation and analysis are disclosed herein. The methods can, for example, be used for isolating and analyzing DNA from various biological samples.

Methods for single-molecule analysis

Methods of double-stranded nucleic acid sequence determination and assembly that are able to identify insertions, deletions, repeat region sizes and genomic rearrangements, for example, are disclosed herein, which can use relatively large labeled nucleic acid fragments to analyze the structure of even larger genetic regions. In some embodiments these methods involve the use of certain parameters which unexpectedly improve overall method performance. In some embodiments these methods involve sample labeling that does not result in the formation of single-stranded nucleic acid fragment labeling intermediaries.

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San Diego, CA, United States of America

Henry B Sadowski