Eli Lilly and Company

Henry Acken Havel

Chin-Ming Chang

Bruce H Frank

Michael Rosario DeFelippis

Virender Kumar Sarin

Michael R De Felippis

Allen H Pekar

Kenneth Francis Mace

Kingman Ng

David N Brems

Diane L Bakaysa

James H Anderson, Jr

A stabilized pharmaceutical composition in the form of a solution for parenteral administration of a parathyroid hormone is described wherein the therapeutically active ingredient is stabilized with a buffer and a polyol. Preferred preparations contain in an aqueous solution human PTH(1-34), mannitol, an acetate or tartrate buffering agent and m-cresol or benzyl alcohol as a preservative.

Stabilized teriparatide solutions

The present invention encompasses compositions wherein a GLP-1 compound is complexed with a basic polypeptide. The compositions provide a prolonged duration of action and can be administered by the pulmonary route.

GLP-1 formulations with protracted time action

A stabilized pharmaceutical composition in the form of a solution for parenteral administration of a parathyroid hormone is described wherein the therapeutically active ingredient is stabilized with a buffer and a polyol. Preferred preparations contain in an aqueous solution human PTH(1&#x2013;34), mannitol, an acetate or tartrate buffering agent and m-cresol or benzyl alcohol as a preservative.

The present invention discloses various parenteral pharmaceutical formulations, which comprise a mixture of a monomeric insulin analog and insulin-NPH. The analog formulations provide a rapid onset and a prolonged duration of action.

Insulin analog formulations

The present invention discloses a human insulin analog hexamer complex and formulations. More specifically, the present invention relates to various parenteral formulations, which comprise: human insulin analogs in a hexamer conformation, zinc ions, and at least three molecules of a phenolic derivative selected from the group consisting of m-cresol, phenol, or a mixture of m-cresol and phenol. The formulation provides a rapid onset of action.

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Indianapolis, IN, United States of America

Henry Acken Havel