Leo Pharmaceutical Products, Ltd.

Leo Pharmaceutical Products Ltd. A/s (l.o Slashed.vens Kemiske Fabrik

Leo Pharmaceutical Products Ltd. A/s (bovens Kemiske Fabrik

Henrik Pedersen

Martin John Calverley

Ernst T Binderup

Gunnar Grue-Sørensen

Kai Holst Hansen

Mikael Tranholm

Use of vitamin D-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin D3-derivatives

The present invention relates to compounds of formula (I) in which formula X is hydrogen or hydroxy; R,and R,which may be the same or different, stand for hydrogen or C,-C,hydrocarbyl; or R,and R,, taken together with the carbon atom bearing the group X, can form a C,C,carbocyclic ring; Q is methylene, ethylene, tri- or tetra-methylene and may optionally be substituted with an oxy group, &mdash;OR,, in which R,is hydrogen, methyl or ethyl; Y is either a single bond or C,-C,hydrocarbylene; and one or more carbons with in R,, R,, and/or Y may optionally be substituted with one or more fluorine atoms, or with a hydroxyl group. The compounds show anti-inflammatory and immunomodulating effects as well as strong activity in inducing differentiation and inhibiting undesirable proliferation of certain cells.

Vitamin D analogues

Vitamin D analogues having a halogen-or azido- substituted side chain

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Roskilde, Denmark

Henrik Pedersen