Leland Stanford Junior University

Deutsches Rheuma-forschungszentrum Berlin

Henrik Mei

Holden Terry Maecker

Axel Ronald Schulz

Lisa Budzinski

Michael Duane Leipold

Beads for use as a control, calibration and/or quantification probe in a mass cytometry assay, wherein the beads are labeled with a heavy metal selected from the group comprising osmium or ruthenium. Also disclosed are beads labeled with a heavy metal exhibiting a surface functionalization that allows for the binding of an affinity reagent, such as a metal-conjugated antibody. Methods are described for the labeling of the beads and usage of the beads for quantification of cell surface receptors or for a compensation of channel crosstalk in mass cytometry assays.

Functionalized metal-labeled beads for mass cytometry

The present disclosure provides analyte-specific binding reagents conjugated with a platinum-containing moiety, e.g., cisplatin, and methods, compositions, and kits for their production and use in assays for analyte detection.

Growing community of inventors

Berlin, Germany

Henrik Mei