Novo Nordisk A/s

Novo Nordisk Biotech, Inc.

Other

Henrik Dalbo Slashedge

Markus Sakari Kauppinen

Stephan Christgau

Lene Nonboe Andersen

Lene Venke Kofod

Hans Peter Heldt-Hansen

Torben Halkier

Thorkild Christensen

John Pedersen

Jo Slashedrli Ringsted

Torben E Jessen

Flemming M Christensen

Per Munk Nielsen

Hans Sejr Olsen

Joan Qi Si

Anette Mullertz

Niels Munk

Hendrik Arie Schols

Kurt Dorreich

Claus Christophersen

Tina Sejersgangrd Jacobsen

Debbie Sue Yaver

Feng Xu

Palle Schneider

Claus Dambmann

Jack Bech Nielsen

Thomas Sandal

Ejner Bech Jensen

Lars Skriver

Karen Gjesing Welinder

Marcel Mischler

Yvette Schnell

Kim Ry Hejnae Butteds

Alphons Gerard Voragen

Martin Schulein

Dorrit A Aaslyng

Jens Breinholt

Sakari Kauppinen

Gitte Budolfsen

Lars Saaby Pedersen

Jan Moller Mikkelsen

Jan Mo Mikkelsen

Kurt D Orreich

Stephen Christgau

Alphons Gerar Voragen

Dorrit A Aae Buttedlyng

An enzyme exhibiting xylanase activity, which enzyme is immunologically reactive with antibody raised against a purified xylanase derived from Aspergillus aculeatus, CBS 101.43. The enzyme may be used for degrading plant cell wall components, e.g., in the preparation of feed, in baking, in the paper and pulp industry, and in connection with separation of wheat into starch and gluten.

Enzymes with xylanase activity from Aspergillus aculeatus

The present invention provides an enzyme with acetyl esterase activity comprising the amino acid sequence IxFGDxYYT(SEQ ID NO: 1), in which x designates any amino acid residue. The enzyme exhibits activity towards acetylated xylan and acetylated mannan and may be used for modifying or degrading plant containing materials.

Enzyme with acetyl esterase activity

Animal feed compositions and methods for treating one or more of soy, pea or rape-seed, or other material derived from Fabales or Cruciferaceae, with an enzyme having rhamnogalacturonase activity, wherein the enzyme having rhamnogalacturonase activity cleaves a rhamnogalacturonan backbone to produce rhamnose as a non-reducing end (RGase II) or cleaves a rhamnogalaturonan backbone to produce galacturonic acid as a non-reducing end.

Enzyme with rhamnogalacturonase activity

The present invention relates to an enzyme with .beta.-(1-6)-endoglucanase activity encoded by a DNA sequence, which DNA sequence a) comprises the DNA sequence shown in SEQ ID No. 3, or b) comprises an analogue of the DNA sequence shown in SEQ ID No. 3, which i) is homologous with the DNA sequences shown in or SEQ ID No. 3, and/or ii) hybridizes with the same oligonucleotide probe as the DNA sequence shown in SEQ ID No. 3, and/or iii) encodes a polypeptide which is homologous with the polypeptide encoded by a DNA sequence comprising the DNA sequence shown in SEQ ID No. 3, and/or iv) encodes a polypeptide which is immunologically reactive with an antibody raised against a purified .beta.-(1-6)-glucanase shown in SEQ ID No. 4 derived from Trichoderma harzianum, CBS 243.71. The present invention also relates to a DNA construct encoding the enzyme, a method of producing the enzyme, an enzyme preparation containing the enzyme, and the use of the enzyme and enzyme preparation for the degradation or modification of .beta.-glucan containing materials.

Enzyme with .beta.-(1-6)- endoglucanase activity

The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus japonicus which (a) has a pH-optimum between 6.5 and 7.0; (b) retains at least 80% of the maximal activity throughout the pH range of 5.5-12; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 20-60.degree. C. The present invention relates to rhamnogalacturonases derived from a strain of Aspergillus aculeatus which (a) has a pH-optimum of about 5.0; (b) retains at least 80% of the maximal activity throughout the pH range of 3-6.5; (c) has a temperature optimum of about 40.degree. C.; and (d) retains at least 80% of the maximal activity throughout the temperature range of 5-50.degree. C.

Rhamnogalacturonase, corresponding DNA sequence, rhamnogalacturonase

An isolated and purified enzyme exhibiting protease activity at a pH of 4-7 which exhibits protease activity in 5% hydrogen peroxide and which is encoded by a DNA sequence which hybridizes to a DNA sequence depicted in SEQ ID NO. 1 or 2.

Enzyme with protease activity

The present invention relates to methods for producing heterologous heme proteins extracellularly comprising transforming a filamentous fungus with a vector comprising a DNA sequence encoding the heterologous heme protein and a DNA sequence encoding a preregion permitting secretion of the expressed heme protein, and culturing the transformed filamentous fungus in a suitable culture medium to produce the heme protein.

Process for producing heme proteins

An enzyme exhibiting xylanase activity, which enzyme is immunologically reactive with an antibody raised against a purified xylanase derived from Aspergillus aculeatus, CBS 101.43. The enzyme may be used for degrading plant cell wall components e.g. in the preparation of feed, in baking, in the paper and pulp industry and in connection with separation of wheat into starch and gluten.

Enzyme with xylanase activity

The present invention relates to DNA sequences encoding a rhamnogalacturonase which comprises

Enzyme with endo-1,3(4)-.beta.- Glucanase activity

Enzyme with pectin lyase activity

DNA encoding an enzyme with endoglucanase activity from Trichoderma

Growing community of inventors

Virum, Denmark

Henrik Dalbo Slashedge