De Novo Pharmaceuticals Limited

Henriette Willems

Raymond Paul Beckett

Paul Gane

Barry Porter

Kenneth Keavey

Compounds of formula (I) are antibacterial agents: wherein: Z is &#x2014;N(OH)CH(&#x2550;O) or &#x2014;C(&#x2550;O)NH(OH); Rrepresents hydrogen, methyl or trifluoromethyl or, except when Z is a radical of formula &#x2014;N(OH)CH(&#x2550;O), a hydroxy, halo or amino group; R, Rand Rindependently represents hydrogen or a group R&#x2014;(D)&#x2014;(ALK)&#x2014; wherein R, D, n, m and ALK are as defined in the claims; or Rand Rtaken together with the nitrogen atom to which they are attached form an optionally substituted monocyclic heterocyclic ring containing from 5 to 7 ring atoms, one of which is the nitrogen atom to which Rand Rare attached and the remaining ring atoms being selected from compatible combinations of carbon, oxygen, sulfur and nitrogen 

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Cambridge, United Kingdom

Henriette Willems