Biochem Pharma Inc.

Thallion Pharmaceuticals Inc.

Cytovia, Inc.

Henriette Gourdeau

Francis J Giles

Sui Xiong Cai

John A Drewe

Shailaja Kasibhatla

Chris M Farnet

François Berger

James B McAlpine

Maxime Ranger

Ben Y Tseng

Denis Labrecque

Pierre Falardeau

Charles Blais

Violetta Dimitriadou

William D Kemnitzer

Bryan Simard

The present invention is directed to a substituted 4H-chromene represented by the Formula 1R, substantially free from the corresponding (S)-stereoisomer: The present invention also relates to the discovery that compound 1R, substantially free from the corresponding (S)-stereoisomer, is an activator of caspases and inducer of apoptosis, as well as an antivascular agent. Therefore, compound 1R, substantially free from the corresponding (S)-stereoisomer, can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs. Compound 1R, substantially free from the corresponding (S)-stereoisomer, also can be used for the treatment of diseases due to overgrowth of vasculature, such as solid tumors and ocular neovascularization.

Substituted 4-aryl-chromene as activator of caspases and inducer of apoptosis and as antivascular agent and the use thereof

This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms by administration of the farnesylated dibenzodiazepinone compound of Formula I via continuous intravenous infusion. The invention includes pharmaceutical compositions comprising the compound of Formula I: 

Methods for administration of a farnesyl dibenzodiazepinone

This invention relates to methods of inhibiting growth and/or proliferation of a neoplastic cell, and methods of treating neoplasms using the farnesylated dibenzodiazepinone compound of Formula I. The invention includes pharmaceutical compositions comprising the compound of Formula I: 

Compositions and methods comprising farnesyl dibenzodiazepinones for treating neoplastic cells and conditions

Methods of treating leukemia

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Montreal, Canada

Henriette Gourdeau