Xayall B.v.

Xyall B.v.

Henricus Rudolphus Kuppens

Evgenia Balmashnova

Hans Van Wijngaarden

Some embodiments are directed to a system and computer-implemented method are provided for determining one or more regions for tissue dissection in a series of pathology slides using a series of images which represent a digitized version of the series of pathology slides. Annotations are obtained for at least two reference images, with each annotation representing a region for tissue dissection in the respective reference image. Annotations are then generated for intermediate images between the reference images on the basis of bidirectional image registration and the subsequent propagation of both annotations to each intermediate image, which annotations are then combined to obtain a combined annotation for each intermediate image. The above measures are well suited to generate annotations for series of pathology slides which contain tissue slices of a tissue of interest having a complex 3D shape.

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Nuenen, Netherlands

Henricus Rudolphus Kuppens