Suprapolix B.v.

Xeltis B.v.

Koninklijke Philips Corporation N.v.

Agfa Gevaert Nv

Agfa-gevaert

Icahn School of Medicine at Mount Sinai

Technische Universiteit Eindhoven

Tagworks Pharmaceuticals B.v.

Symo-chem B.v.

Eutechpark Mmp1.28

Trained Therapeutix Discovery, Inc.

Xeltis Ag

Voltea B.v.

Henricus Marie Janssen

Anton Willem Bosman

Egbert Willem Meijer

Gaby Maria Leonarda Van Gemert

Gaby Maria Leonarda Hoorne-Van Gemert

Patricia Yvonne Wilhelmina Dankers

Tristan Mes

Johan August Loccufier

Luc J Vanmaele

Ronny Mathieu Versteegen

Joris Wilhelmus Peeters

Travis Wayne Baughman

Pieter Fransen

Dirk Jan Broer

Wolter Ten Hoeve

Marc Stefan Robillard

Martijn Antonius Johannes Cox

Franciscus Petrus Thomas Baaijens

Albert Van Der Wal

Hank Robert Reinhoudt

Serge Hendrikus Mathijs Söntjens

Raffaella Rossin

Tom Lavrijsen

Anandkumar Nandakumar

Carolina Victoria Catharina Bouten

Rintje Pieter Sijbesma

Freek Johannes Maria Hoeben

Bas Van Genabeek

Arthur Henry Antoon Marie Van Onzen

Willem J M Mulder

Rudolf Mathias Johannes Nicolaas Lamariche

Anton William Bosman

Aafke Tessa Ten Cate

Dimphna Johanna Maria Van Beek

Sandrine Chodorowski-Kimmès

Serge Hendrikus Mathÿs Söntjens

Emial Pesters

Aurelie Brizard

Michel Henri Chrétien Joseph Van Houtem

Serge Hendrikus Mathijs SÖNTJENS

Michel Henri Chretien Joseph Van Houtem

Gaby Maria Leonarda Hoorne - Van Gemert

Trayvis Wayne Baughman

Disclosed is an advancement in provoked chemical cleavage. Thereby the invention provides the use of a diene as a chemically cleavable group attached to a Construct, and the use of a dienophile to provoke the release of the Construct by allowing the diene to react with a dienophile capable of undergoing an inverse electron demand Diels Alder reaction with the diene. The invention includes a kit for releasing a Construct Cbound to a Trigger T, the kit having a tetrazine and a dienophile, wherein the Trigger is the tetrazine. The invention also includes the use of the formation of a pyridazine by reacting a tetrazine having a Construct Cbound thereto and a dienophile, as a chemical tool for the release, in a chemical, biological or physiological environment, of the Construct.

Cleavable tetrazine used in bio-orthogonal drug activation

The present invention relates to supramolecular biomedical polymers comprising quadruple hydrogen bonding units and to a process for preparing such a supramolecular biomedical polymer and porous biomedical implants thereof. The supramolecular biomedical polymers are particularly suitable for the production of porous biomedical implants that need high strength, elasticity, durability, and slow biodegradation, e.g. medical implants for living tissue regeneration within a mammal, such as the treatment of cardio-vascular diseases, medical prolapses, and hernias.

Supramolecular biomedical polymers

Provided herein are compounds of Formula (I), as well as compositions comprising a compound of Formula (I) and uses thereof.

Compounds for regulating trained immunity, and their methods of use

The present invention relates to a thermoplastic elastomer according to the formula [AB], wherein A represents a soft block and B represents a hard block. The present invention further relates to a process for the preparation of the thermoplastic elastomer. The thermoplastic material is in particular suited for biomaterial applications, for example for implants and tissue engineering applications and for purposes including scaffolding material applications, e.g. for tissue engineering purposes.

Strictly segmented thermoplastic elastomers as biodegradable biomaterials

The present invention relates to improved hydrogel materials using water gellants that are comprised of polymer backbones P to which hydrogen bonding 4H-units are covalently attached via a hydrophobic linker L. Optionally, the hydrogel contains additional ingredients or additives. These new reversible hydrogels can easily be fine-tuned in their mechanical performance and function and are especially suitable for biomedical applications.

Strong reversible hydrogels

This disclosure relates to new injectable hydrogel materials that consist of water gellants comprising linear hydrophilic polymers that comprise hydrogen bonding units in the backbone combined with cross-linkable end groups, resulting in dynamic yet firm hydrogel materials that are easily processable, are highly elastic, show adhesive properties and are self-healing and are especially suitable for biomedical applications.

Durable hydrogen bonded hydrogels

The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or biomedical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.

Modular bioresorbable or biomedical, biologically active supramolecular materials

The disclosure lies in the field of regenerative medicine and relates to an implant having a matrix material, and a method for manufacturing an implant having matrix material. The disclosure further relates to a crimped implant.

Implant

A method of using a fluorinated polymer having a glass transition temperature below 40 C as a contrast agent inF magnetic resonance imaging (MRI) of a solid object, said solid object comprising said contrast agent. The invention relates to a solid object comprising a structural component and an imaging component, wherein the imaging component is at least one fluorinated polymer. The invention relates to a method forF MRI in solid state using a contrast agent comprising a fluorinated polymer as well as a method for in vivo visualizing a scaffold. It further relates to a method for in vivo monitoring the degradation of a solid object in time, wherein the degradation is monitored in time by usingF MRI to visualize the solid object, and wherein the amount of degradation of the solid object is determined based on the decrease in the visibility of the amount ofF.

Use of a fluorinated polymer as a contrast agent in solid state 19F magnetic resonance imaging (MRI), scaffold comprising said polymer and use thereof

The invention relates to a process for the preparation of a supramolecular polymer comprising 1-50 4H-units, in which a 4H building block is reacted with a prepolymer, wherein a 4H building block comprises a 4H-unit and a reactive group according to Formula (I):4H-(L-F)&#x2003;&#x2003;(I)wherein 4H represents a 4H-unit, L represents a divalent, trivalent, tetravalent or pentavalent linking group, Frepresents a reactive group, and r is 1-4, is reacted with a pre-polymer comprising a complementary reactive group, wherein the reaction mixture comprising said 4H building block and said polymer comprises less than 10 wt. % of a non-reactive organic solvent, based on the total weight of the reaction mixture.

Process for the preparation of a supramolecular polymer

The present invention relates to a supramolecular polymer comprising 1-50 4H-units, said supramolecular polymer being obtainable by reacting at least one monomeric building block with a prepolymer. The present invention further relates to articles or compositions comprising the supramolecular polymer, in particular articles or compositions selected from the group consisting of decorative, thermo-reversible, or self-healing coatings, adhesive compositions, sealing compositions, thickeners, gelators and binders.

Supramolecular polymers from low-melting, easily processable building blocks

The present invention relates to a modular supramolecular bioresorbable or biomedical material comprising (i) a polymer comprising at least two 4H-units and (ii) a biologically active compound. Optionally, the supramolecular bioresorbable or bio medical material comprises a bioresorbable or biomedical polymer as third component to tune its properties (mechanical and bioresorption properties). The supramolecular bioresorbable or biomedical material is especially suitable for biomedical applications such as controlled release of drugs, materials for tissue-engineering, materials for the manufacture of a prosthesis or an implant, medical imaging technologies.

The present invention relates to a supramolecular compound comprising a low molecular weight, apolar compound, said low molecular weight, apolar compound having a melting point of below 45&#xb0; C., a molecular weight of about 80 to about 1500 amu and a HLB-value of lower than 8, said low molecular weight, apolar compound bearing a single 4H-unit per molecule. The supramolecular compound according to the present invention may be used in coating, ink, toner, resin, lacquer, adhesive or glue compositions.

High flow supramolecular compounds

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Eindhoven, Netherlands

Henricus Marie Janssen