Dsm IP Assets B.v.

Arlanxeo Netherlands B.v.

Dsm B.v.

Lanxess Elastomers B.v.

Henricus Johannes Arts

Edwin Ijpeij

Martin Alexander Zuideveld

Felix Beijer

Aylvin Jorge Angelo Athanasius Dias

Franciscus Johannes Marie Derks

Gerardus Van Doremaele

Francis Van Der Burgt

Noel L Davison

Ruud Jozef Regina Wilhelmus Peters

Anne Marie Persson

Victor Fidel Quiroga Norambuena

Alexandra Berthoud

Richard Thomas William Scott

Mirko Kranenburg

Peter Windmuller

Gerardus J M Gruter

Gerardus Henricus Josephus Van Doremaele

Gerard Van Doremaele

Ramon H A M Meijers

Thomas Dikken

Remco Dinkelberg

Felix Hugo Beijer

Gerardus Henricus Van Doremaele

Peter Jozef Windmuller

Edwin Gerard Ijpeij

Anne Maria Persson

Stijn Witters

Peter Jozef Hubert Windmuller

Richard Scott

Wendy Hyett

The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 μm in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.

Method of making an osteoconductive fibrous article and a medical implant comprising such osteoconductive fibrous article

There is disclosed certain hyperbranched polyester amides with end groups selected from: esters or amides of betaine-type end groups useful in various end uses such as a flocculent.

Hyperbranched polymers

The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal Rmeans is a substituent comprising a heteroatom of group 15, through which Ris bonded to the imine carbon atom; R-Rare the same or different and each represents a hydrogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R-Rmay be linked to each other to form a ring; R-Rare the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C1-10 alkyl group, an optionally substituted C1-10 alkoxy group, an optionally substituted C6-20 aryl group, an optionally substituted C6-20 aryloxy group, an optionally substituted C7-20 aralkyl group, an optionally substituted C7-20 aralkyloxy group, a silyl group substituted with optionally substituted C1-20 hydrocarbon group(s), a C1-20 hydrocarbon-substituted amino group or the adjacent R-Rmay be linked to each other to form a ring; L is an optional neutral Lewis basic ligand, and j is an integer denoting the number of neutral ligands L; and X is an anionic ligand, and r is an integer denoting the number of anionic ligands X and wherein the two cyclopentadienyl-amidinato-metal-containing moieties as in the brackets are the same or different. 

Bimetallic complex comprising cyclopentadienyl and amidine ligands

The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl Colefin in the presence of an ionic catalyst, comprising an organometallic compound and an activator, and optionally a scavenger.

Polymerization catalyst comprising amidine ligand

The invention relates to a process for the preparation of a hydrocarbylated metal organic compound, comprising a hydrocarbyl group, a spectator ligand and optionally a ligand, by contacting a metal-organic reagent with a spectator ligand in the presence of at least 2 equivalents of a hydrocarbylating agent. The invention further relates to a hydrocarbylated metal organic compound according to the following formula containing a spectator ligand S equal to (Ar&#x2014;Z&#x2014;)Y(&#x2014;Z-DR'), wherein Y represents the an anionic moiety of S bonded to M of the metal-organic compound, Z an optional bridging group between the Y moiety and the DR&#x2032;and/or Ar group, D an electron donating hetero atom chosen from group 15 or 16, R&#x2032; an optional substituent, Ar an electron-donating aryl group, n the number of R&#x2032; groups bonded to D, q and s integers with q+s&#x2267;1, wherein Y is an imine radical, or wherein the electron donating hetero atom containing group DR&#x2032;&#x2014;is a ketimide, phosphinimide, guanidine, or iminoimidazoline, or a combination thereof.

Method of preparing a hydrocarbylated metal-organic compound

A process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula (1) or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula (2) in the presence of at least 1, respectively at least 2 equivalents of a base, with Y&#x2550;N&#x2014;R as formula (1), wherein Y is selected from a substituted carbon, or nitrogen atom and R represents a substituent, and with M(L)k(L)l(L)m(L)nas formula (2), wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L, L, L, and Lrepresent a ligand or a group 17 halogen atom on M and may be equal or different, X represents a group 17 halogen atom, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor.

Process for the preparation of a metal-organic compound comprising at least one imine ligand

The invention relates to a process for the production of an organometallic compound according to formula (1): MALYXR(formula 1) where: M is a metal of groups 3-13 or the lanthanide series, and p is the valency of the metal M, A represents an anionic spectator ligand whose valency v is 1 or 2, Y is a spectator ligand represented by formula (2): wherein the spectator ligand is covalently bonded to the metal M via the imine nitrogen atom, Subis a substituent, which comprises a group 14 atom through which SUbis bonded to the imine carbon atom, Subis a substituent, which comprises an atom of groups 15-16, through which Subis bonded to the imine carbon atom, suband submight be connected to each other forming a ring system, r is an integer&#x3e;0, L is an optional neutral Lewis basic ligand, j is an integer denoting the number of neutral ligands L, X is an halide, and R is an anionic ligand, wherein an organometallic reagent according to formula (3), MALX(formula 3), is contacted with an alkylating agent, thus forming a precursor in which at least one of the halide atoms is replaced by an anionic ligand R that may be independently selected from the group consisting of alkyl, arylalkyl, aryl, or a combination thereof, which precursor is subsequently contacted with an imine according to formula (2). 

Process for the preparation of a metal-organic compound comprising a spectator ligand

The invention relates to a process for the preparation of a metal-organic compound, comprising at least one phosphinimine ligand, characterized in that the HA adduct of a phosphinimine ligand according to formula (1) is contacted with a metal-organic reagent of formula (2) in the presence of 1, respectively 2 equivalents of a base, wherein HA represents an acid, of which H represents its proton and A its conjugate base, with Y&#x2550;N&#x2014;H as formula (1), and M(L)(L)(L)(L)X as formula (2), and wherein Y is a substituted phosphorous atom, and M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5 L, L, L, and Lrepresent a ligand or a group 17 halogen atom on M and may be equal or different, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+1=V, and X represents a group 17 halogen atom. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerization compatible base, which metal-organic compound is activated anywhere in, or before a polymerization reactor.

Process for the preparation of an metal-organic compound comprising at least one imine ligand

The invention relates to a process for the preparation of a metal-organic compound, comprising at least one phosphinimine ligand, characterized in that the HA adduct of a phosphinimine ligand according to formula (1) is contacted with a metal-organic reagent of formula (2) in the presence of at least 2 equivalents of a base, wherein HA represents an acid, of which H represents its proton and A its conjugate base, with Y&#x2550;N&#x2014;H as formula (1), and M(L)(L)(L)(L)X as formula (2), and wherein Y is a substituted phosphorous atom, and M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5 L, L, L, and Lrepresent a ligand or a group 17 halogen atom on M and may be equal or different, k, l, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V, and X represents a group 17 halogen atom. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor.

The invention related to a process for the polymerization of at least one aliphatic Cor aromatic Chydrocarbyl mono- or multiolefin in the presence of a catalyst and an aluminum comprising co-catalyst, wherein the catalyst comprises a composition of a metal-organic reagent, a spectator ligand and optionally at least one equivalent of a hydrocarbylating agent. The invention further relates to a polymer obtainable by the process of the invention.

Process for the preparation of a polyolefin

The invention relates to a process for the preparation of a metal-organic compound, comprising at least one imine ligand, characterized in that an imine ligand according to formula 1, or the HA adduct thereof, wherein HA represents an acid, of which H represents its proton and A its conjugate base, is contacted with a metal-organic reagent of formula 2 in the presence of at least 1, respectively 2 equivalents of an inorganic or metal-organic base, wherein Y&#x2550;N-R (formula 1), Y is selected from a substituted carbon, nitrogen or phosphorous atom, R represents a proton, a protic or an aprotic substituent, and the metal organic compound is: M(L)k(L)l(L)(L)X (formula 2) wherein: M represents a group 4 or group 5 metal ion, V represents the valency of the metal ion, being 3, 4 or 5, L, L, L, and Lrepresent ligands on M and may be equal or different, X represents a group 17 halogen atom, and k, 1, m, n=0, 1, 2, 3, 4 with k+l+m+n+l=V. The invention further relates to a process for the preparation of a polyolefin by making a metal-organic compound according to the process of the invention, wherein the base is an olefin polymerisation compatible base, which metal-organic compound is activated anywhere in, or before a polymerisation reactor.

The invention related to a process for the polymerization of at least one aliphatic or aromatic hydrocarbyl C2-20 mono- or multiolefin in the presence of a catalyst and a boron comprising co-catalyst, wherein the catalyst comprises a composition of a metal-organic reagent, a spectator ligand and optionally at least one equivalent of a hydrocarbylating agent. The invention further relates to a polymer obtainable by the process of the invention.

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Munstergeleen, Netherlands

Henricus Johannes Arts