Teva Pharmaceutical Industries Limited

Medgenix Group S.a.

Henri Wantier

Dominique Delacroix

Fabienne Mathieu

Marc Baudrihaye

Brigitte Leclef

Andre Trouet

Patrick Cerfontaine

Jean-Marie Nicolas

Microspheres which are a matrix of a biocompatible and biodegradable polymer which is soluble in an organic solvent which is immiscible in water, within which a water-soluble substance is uniformly distributed, and wherein the residual level of toxic solvent in the microspheres is lower than 1.5% by weight, progressively and continuously releases the substance over a period of at least 8 days when the microspheres are placed in an aqueous physiological environment, with a reduced or substantially absent first phase of accelerated release. A process for producing such microspheres is provided.

Microspheres for the controlled release of water-soluble substances and

The subject of the present invention is a process for preparing microparticles of the microsphere type of a water-soluble substance and a biocompatible and biodegradable polymer controlling the kinetics of release of the said substance consisting of a matrix of the said polymer within which the said water-soluble substance is regularly dispersed, characterized in that

Preparation of microparticles for controlled release of water-soluble

The present invention relates to a process for preparing lipid microparticles of microcrystalline appearance, of a water-insoluble substance possessing an affinity for phospholipids and of at least one phospholipid, the microparticles being stable in suspension in an aqueous solution, characterized in that:

Process for preparing lipid microparticles

Growing community of inventors

Dour, Belgium

Henri Wantier