William Marsh Rice University

Baylor College of Medicine

Other

Henri Justino

Daniel A Harrington

Kwonsoo Chun

Daniel Harrington

Some embodiments are directed to methods for serially expanding an artificial heart valve within a pediatric patient. For example, the artificial heart valve can be implanted into the pediatric patient during a first procedure, and then expanded during a second procedure to accommodate for the pediatric patient's growth. Some embodiments include introducing an expander into the implanted valve when the frame is expanded to a first working diameter, and then actuating the expander to expand the frame to a second working diameter greater than the first working diameter, to accommodate for the pediatric patient's growth.

Serially expanding an artificial heart valve within a pediatric patient

Some embodiments are directed to a transcatheter and serially-expandable artificial heart valve, e.g., to be minimally-invasively implanted into a pediatric patient during a first procedure, and then expanded during a second procedure to accommodate for the pediatric patient's growth. Some embodiments include an expandable frame having a compressed, delivery configuration, and an expanded, deployed configuration, in which the valve is implantable within the patient. The valve can have a first working condition when the frame is expanded to a first diameter and a second working condition when the frame is expanded to a second diameter greater than the first diameter. The valve can include a plurality of leaflets configured to accommodate the expansion of the frame and growth of the patient.

Transcatheter and serially-expandable artificial heart valve

There is described a prosthetic valve to be inserted into a body lumen, the valve having leaflets that are spread apart during forward flow of fluid to create an orifice, and the leaflets coming into contact with each other during reverse flow of fluid, thereby impeding the reverse flow of fluid, the valve comprising: a hollow, cylindrical stent having an inner surface and an outer surface, and having a first and a second open end; and valve means formed from a single tubular membrane, the membrane mounted to the stent, the membrane having a graft portion internally folded and bonded to itself at a plurality of points to form pouches such that the leaflets extend from the pouches, and a sleeve portion on an outer surface of the stent to secure the membrane thereto.

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Houston, TX, United States of America

Henri Justino