Jouveinal, S.a.

Warner-lambert Company

Institut De Recherche Jouveinal

Henri Jacobelli

Jean-Louis Junien

Xavier B Pascaud

Alain A Calvet

Agnes G Grouhel

Gilbert G Aubard

Bernard Gaudilliere

Joseph Armand Picard

Michael William Wilson

Alain P Calvet

Francois J Roman

Charles Andrianjara

Francine Breuzard

Francois Roman

A compound selected from those of formula (I):

Alkynylated quinazoline compounds

A compound selected from those of formula (I):in which:

Triazolo compounds as MMP inhibitors

New cycloalkylalkylamines which are sigma-receptor ligands of formule (I) ##STR1## in which: R.sub.1 is H or lower alkyl; X and Y are H, OH, lower alkyl, lower alkoxy, halogen or nitrile; V.sub.1 and V.sub.2 together form a double bond attached to an oxygen atom or to a hydroxyimino radical, or are linked as an ethylenedioxy chain; A represents a valency bond, an oxygen atom, a methylene or an ethylene group; m is equal to 0, 1 or 2; n has the value of an integer from 1 to 5. Psychotropic drug which is also useful in gastroenterology.

Cycloalkylalkylamines which are sigma-receptor ligands and their

(+)-1-[(3,4,5-trimethoxy)-benzyloxymethyl]-1-phenyl-N,N-dimethyl-n-propylam ine of formula ##STR1## is a medicament of use in gastroenterology.

Use of

(+)-1-[(3

The present invention relates to propanamines of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted in an identical or different manner with halogen atoms, or lower alkyl, lower haloalkyl or lower alkoxy radicals; R2 is a lower alkyl radical, R3 and R4 are a hydrogen atom or a lower alkyl, lower alkenyl or lower cycloalkyalkyl radical, R5 is a 5-to 7-membered cycloalkyl radical or a phenyl radical, and W represents a heterocycle .dbd.C[Q--(CH.sub.2).sub.n --Q] in which Q is an oxygen or sulfur atom and n is 2 or 3, and their acid addition salts with pharmaceutically acceptable acids. The invention also relates to antidiarrheal pharmaceutical compositions comprising the claimed propanamines.

Propanamines, their pharmacological properties and their application as

A compound which is a propanamine of general formula (I) ##STR1## in which: R1 is a phenyl radical optionally mono-, di- or trisubstituted,

Propanamines, their pharmacological properties and their application for

Growing community of inventors

Paray Vieille Poste, France

Henri Jacobelli