Janssen Pharmaceutica Nv

Janssen Pharmaceutica

Henri E L Moereels

Jan Heeres

Donald William Ludovici

Michael Joseph Kukla

Paul A J Janssen

This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein Rand Rare each independently selected from hydrogen; hydroxy; amino; optionally substituted Calkyl; Calkyloxy; Calkylcarbonyl; Calkyloxycarbonyl; Ar; mono- or di(Calkyl)amino; mono- or di(Calkyl)-aminocarbonyl; dihydro-2(3H)-furanone; or Rand Rtaken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(Calkyl)amino-Calkylidene; Ris hydrogen, Ar, Calkylcarbonyl, Calkyl, Calkyloxy-carbonyl, Calkyl substituted with Calkyloxycarbonyl; and R, R, R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted Calkyl; Calkenyl; Calkynyl; Ccycloalkyl; Aris optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

Substituted diamino-1,3,5-triazine derivatives

This invention concerns the compounds of formulathe pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein Rand Rare each independently selected from hydrogen; hydroxy; amino; optionally substituted Calkyl; Calkyloxy; Calkylcarbonyl; Calkyloxycarbonyl; Ar; mono- or di(Calkyl)amino; mono- or di(Calkyl)aminocarbonyl; dihydro-2(3H)-furanone; or Rand Rtaken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(Calkyl)amino-Calkylidene; Ris hydrogen, Ar, Calkylcarbonyl, Calkyl, Calkyloxycarbonyl, Calkyl substituted with Calkyloxycarbonyl; and R, R, R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted Calkyl; Calkenyl; Calkynyl; Ccycloalkyl; Aris optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

This invention concerns the compounds of formula the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein Rand Rare each independently selected from hydrogen; hydroxy; amino; optionally substituted Calkyl; Calkyloxy; Calkylcarbonyl; Calkyloxycarbonyl; Ar; mono- or di(Calkyl)amino; mono- or di(Calkyl)-aminocarbonyl; dihydro-2(3H7)-furanone; or Rand Rtaken together may form pyrrolidinyl, piperidinyl, morpholinyl, azido or mono- or di(Calkyl)amino-Calkylidene; Ris hydrogen, Ar, Calkylcarbonyl, Calkyl, Calkyloxy-carbonyl, Calkyl substituted with Calkyloxycarbonyl; and R, R, R, Rand Rare each independently selected from hydrogen, halo, Calkyl, Calkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy; L is optionally substituted Calkyl; Calkenyl; Calkynyl; Ccycloalkyl; Aris optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. It further relates to new compounds being a subgroup of the compounds of formula (I), their preparation and compositions comprising them.

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Ekeren, Belgium

Henri E L Moereels