Boehringer Ingelheim International Gmbh

Dr. Karl Thomae Gmbh

Centrexion Therapeutics Corporation

Boehringer Ingelheim Pharma Gmbh & Co Kg

Orexo Ab

Boehringer Ingelheim Pharma Kg

Other

Karl Thomae Gmbh

Karl Thomas Gmbh

Henri Doods

Klaus Rudolf

Dirk Stenkamp

Stephan Georg Mueller

Gerhard Schaenzle

Kirsten Arndt

Wolfgang Eberlein

Philipp Lustenberger

Wolfhard Engel

Raimund Kuelzer

Norbert Hauel

Marco Santagostino

Roland Pfau

Gerhard Mihm

Fabio Paleari

Henning Priepke

Angelo Ceci

Alexander Dreyer

Ingo Konetzki

Annette Schuler-Metz

Michael Entzeroth

Rainer Walter

Dirk Gottschling

Annekatrin Charlotte Heimann

Doris Riether

Iris Kauffmann-Hefner

Achim Sauer

Florian Paul Christian Binder

Janet Rachel Nicholson

Norbert Mayer

Georg Dahmann

Wolfgang Wienen

Benjamin Pelcman

Klaus Klinder

Juergen Mack

Eckhart Bauer

Gerhard Hallermayer

Robert Roenn

Klaus-Dieter Willim

Riccardo Giovannini

Gunter Trummlitz

Marco Ferrara

Iain Lingard

Rocco Mazzaferro

Stefan Just

Yunhai Cui

Edgars Suna

Dimitrijs Lubriks

Heike-Andrea Wieland

Helmut Pieper

Horst Dollinger

Franz Esser

Gerd Schnorrenberg

Heiner Ebel

Marcus Schindler

Jurgen Krause

Harald Ziegler

Heike Andrea Wieland

Birgit Jung

Stefan Peters

Kai Gerlach

Rudolf Hurnaus

Thierry Bouyssou

Dieter Wiedenmayer

Enzo Cereda

Alexander Heim-Riether

Rudolf Hammer

Volker Trach

Stephan George Mueller

Adrian De Jonge

Welfhard Engel

Richard Reichl

Rudlof Klaus

Florian Binder

This invention relates to novel (Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles and their use as CB2 cannabinoid receptor agonists, pharmaceutical compositions containing the same, and their use for the treatment of CB2 receptor mediated disorders or conditions.

(cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

(Cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

3-aza-bicyclo[3.1.0]hexane-6-carboxylic acid amide derivatives which are agonists of somatostatin receptor subtype 4 (SSTR4), useful for preventing or treating medical disorders related to SSTR4.

Somatostatin receptor subtype 4 (SSTR4) agonists

There are provided compounds of formula (I), wherein R, R, R, Q, Q, Q, Q, L and A have meanings given in the description, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a member of the MAPEG family is desired and/or required, and particularly in the treatment of inflammation and/or cancer. 

1H-benzimidazole-5-carboxamides as anti-inflammatory agents

This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin Esynthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R, R, R, R, R, Q, Q, Q, Z, Z, Z, Zand W have meanings given in the description.

Compounds

The present invention relates to the new compounds of general formula I wherein A, U, V, X, Y, R, Rand Rare defined as stated hereinafter, the tautomers, the isomers thereof, the diastereomers, the enantiomers, the hydrates, the mixtures and the salts thereof as well as the hydrates of the salts, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, medicaments containing these compounds, their use and processes for preparing them.

Pyrimidine derivatives which are CGRP&#x2014;antagonists

Disubstituted tetrahydrofuranyl compounds of general formula I of which the following are exemplary: 

Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists

The present invention relates to compounds of general formula I in which A, L, M, Q, Q, Q, R, R, R, R, R, W, X, Y, Z, Z, Zare defined in the description, the salts thereof, particularly the physiologically acceptable salts thereof. The compounds are of potential utility in the treatment and/or prevention of inflammatory diseases and associated conditions, in particular, in the treatment and/or prevention of pain. The invention also relates to the use of such compounds as medicaments, to pharmaceutical compositions containing them, and to their preparation.

1H-benz imidazole-5-carboxamides as anti-inflammatory agents

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Warthausen, Germany

Henri Doods