Sanofi

Elf Sanofi

Sanofi Sa

Henri Desmolin

Michel Morre

Daniel Aubert

Francis Blanc

Lucette Sindely

The microbeads are composed of a core containing the active ingredient and a microporous membrane, insoluble in aqueous medium, consisting of a film-forming polymer, a plasticizer and a filling material. The membrane has a thickness such that diltiazem is released in vitro at an approximately constant rate for at least 6 hours after a latent period of less than one hour. The active ingredient can be intimately mixed with the core or included in a polyvinyl pyrrolidone layer coating an inert grain. The sustained-release microbeads are formed by application to the core of a dispersion of the constituents of the membrane in a solvent and evaporation of the solvent. The pharmaceutical compositions consist of capsules containing the microbeads. They are administered orally one or twice per day, depending on the dose, for the treatment of angina or hypertension.

Microbeads of diltiazem, a process for their manufacture and a

New pharmaceutical composition based on valproic acid and one of the pharmaceutically acceptable salts thereof, obtained by a new galenic preparation process which makes it possible to improve and simplify the galenic production, this composition also containing excipients which favorably modify its kinetics and its bioavailability.

Pharmaceutical composition based on valproic acid and a process for

Valproic acid preparations

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Merignac, France

Henri Desmolin