Sanofi

C M Industries

Centre National De La Recherche Scientifique

Institut National De La Sante Et De La Recherche Medicale

Clin Midy

Sanofi Sa

Societe Anonyme Dite : Sanofi

Henri Demarne

Romeo Roncucci

Madeleine Mosse

Joseph Diaz

Paul-Henry Schmelck

Jean Wagnon

Jean Martinez

Bertrand Castro

Jean-Pierre Bali

Andre Hallot

Yves Beuzard

Bernard Sebille

Richard Magous

Robert Filhol

Vincenzo Proietto

Pierre Tozzolino

Dino Nisato

Claude Bernhart

Jacqueline Lansen

Jean Rosa

Jean-Paul Castaigne

Robert Filhoi

The invention concerns compositions with antimicrobial activity. These compositions contain a benzoic acid derivative with the formula: ##STR1## in which: A represents a straight or branched alkyl chain with 3 to 4 carbon atoms,

Antimicrobial compositions containing benzoic acid derivatives for use

The present invention relates to new aromatic derivatives of formula: ##STR1## wherein: Alk is an alkylene group with 1 to 10 carbon atoms,

Antimicrobial aromatic derivatives substituted by an (omega amino)

A process for the synthesis, in liquid phase and by fragments, of hGRF 1-44 and hGRF 1-40. This process consists in coupling, one after the other and in the order of the sequence of the GRF,

Synthesis of hGRF (Somatocrinin) in liquid phase and intermediate

The present invention relates to benzamidine derivatives corresponding to the general formula ##STR1## in which: A represents a linear or branched alkyl chain containing from 3 to 9 carbon atoms; and

Benzamidine derivatives

Synthesis of hGRF (somatocrinin) in liquid phase and intermediate

The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising: coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group; selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

Synthesis of hpGRF(Somatocrinin) in liquid phase and intermediate

The invention relates to novel thiosulfonate derivatives of general formu a:

Thiosulfonate derivatives for inhibiting malformation or destruction of

The invention relates to pharmaceutical or veterinary compositions for initing the malformation or destruction of red blood corpuscules due to a genetic modification of haemoglobin or to parasites, compositions comprising, as active ingredient, at least one thiosulfonate derivative of general formula:

Pharmaceutical or veterinary compositions containing thiosulfonate

Benzoic acid derivatives with the general formula: ##STR1## in which: A represents a straight or branched alkyl chain with 5 to 10 carbon atoms,

Benzoic acid derivatives process for preparation and application as

The invention relates to the peptides of the formula: ##STR1## in which: R.sub.1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl groups;

Reduced peptides which inhibit gastric secretion, process for their

The invention relates to the peptides of the formula: ##STR1## in which: R represents hydrogen or a protecting group for the terminal amine group, such as t-butoxycarbonyl (Boc), benzyloxycarbonyl (Z) or lower alkanoyl;

Tripeptide and tetrapeptide esters which inhibit gastric secretion,

The present invention relates to cyclic dithiodiacetamides with action inhibiting the malformation or the destruction of the red blood corpuscles due to a genetic modification of the haemoglobin or to parasites, of formula: ##STR1## in which X is a direct bond, an atom of oxygen or of sulfur, a methylene group, an ethylene group or an N--R group, where R is an atom of hydrogen or a lower alkyl group, lower (hydroxy)alkyl group, lower alkanoyl group or a phenyl group; to their possible pharmaceutically acceptable salts; to a process for preparing them from a dithiodiacetate or a mercaptoacetate of lower alkyl by transamination and possible oxidation; and to pharmaceutical compositions containing them as active ingredients, useful for the treatment for example of drepanocytosis, or sickle cell anaemia, of malaria and of babebiosis.

Cyclic dithiodiacetamides and compositions containing them

The invention relates to peptides of general formula:

Novel peptidic derivatives inhibiting gastric secretion, process for

Benzodiazepines of formula ##STR1## wherein R3 is methyl or ethyl and R4 is chlorine or fluorine are useful therapeutic agents for the treatment of neuropsychic disturbances.

Method of treating neuropsychic disturbances by benzodiazepine

The invention relates to synthesis of hpGRF (Somatocrinin) in liquid phase and to intermediate peptides, comprising:--coupling, one after the other and in the order of the sequence of the GRF, the fragments in which: (a) the side acid functions of the aspartic and glutamic acids and the side amine function of the lysine are protected by protector groups stable in the conditions of deprotection of the group Boc, (b) the guanidine function of the arginine is protected by protonation, and (c) the N-terminal amino acid is protected on the amine by the Boc group;--selectively eliminating the group Boc from the N-terminal amine of the peptide in phase of elongation by hydrolysis with trifluoroacetic acid, said coupling being effected in an aprotic polar solvent and--eliminating, at the end of sequence, all the protector groups by hydrolysis with the aid of a 0.1 to 1M solution of methanesulfonic or trifluoromethanesulfonic acid in trifluoroacetic acid.

Growing community of inventors

Montpellier, France

Henri Demarne