Laboratoires Sarget

Henri Combier

Gisele Prat

Henri Pontagnier

Francois Fauran

Annie Thibault

Claude Andre-Mouries

The present invention concerns a new triterpenic saponin derived from caulophyllogenin, the process for extracting it from varieties of Chrysanthellum, and its therapeutic use. This saponin is characterized as being the ester of O-.beta.-D-glucosyl-3.beta.-caulophyllogenin and an oligosaccharide comprising two units of L-rhamnose and two units of D-xylose. It is extracted from vegetable matter and purified using pressurized liquid preparative chromatographic techniques. This saponin is useful in human and veterinary therapeutics in phlebology, rheumatology, and traumatology.

Triterpenic saponin having pharmacological potency

A plant extract rich in triterpenic constituents obtained from chrysanthellum and containing as principle component a triterpenic saponin derivative of echinocystic acid whose glycoside contains rhamnose, glucose and xylose may be prepared by extraction of chrysanthellum plants. The extract has been shown to have pharmacological activity, especially analgesic, anti-inflammatory, capillaroprotective and anti-ulcer activity.

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Lyon, France

Henri Combier