Case Western Reserve University

Other

Henri Brunengraber

Catherine Bomont

France David

Peter T Hallowell

Bernard R Landau

Sylvain Desrochers

Kevin D Cooper

Takhar Kasoumov

Khadija Quinze

Hermann Dugas

A pyruvate compound suitable for cosmetically or dermatologically administering to the skin and for use in treating diabetic ketosis or other medical treatments. The compound includes a pyruvate selected from the group of pyruvate thioester, dihydroxyacetonepyruvate, and an ester of pyruvate and a sugar or a polyol.

Medical uses of pyruvates

The invention comprises a novel pyruvate compound for the treatment of prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs ethanol intoxication oras s foodstuff. The novel pyruvate compound is particularly a puruvate thiolester, a glucerol-pyruvate ester or a dihydoxyacetone-pyruvate ester.

Pyruvate compounds and methods for use thereof

The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia, diabetic effects, cholesterol levels, injured organs, ethanol intoxication or as a foodstuff. The novel pyruvate compound is particularly a pyruvate thiolester, a glycerol-pyruvate ester or a dihydoxyacetone-pyruvate ester.

The invention comprises a novel pyruvate compound for the treatment or prevention of reperfusion injury following ischemia. The novel pyruvate compound is particularly a pyruvate thiolester. Preferably, the thiol is selected from a cysteine or a methionine amino acid. In a particularly preferred form, the compound is an N-acetyl ethyl ester of the cysteine or methionine amino acid. The most preferred compound is: ##STR1##

Pyruvate thiolester for the prevention of reperfusion injury

In accordance with the present invention, there is provided a composition for parenteral and oral nutrition, which comprises a compound of Formula I: ##STR1## wherein R.sub.2 is methyl or ethyl;

Composition for parenteral and oral nutrition

Compositions for parenteral nutrition comprising a nutritionally effective amount of a compound of the following formula: ##STR1## R.sup.2 is methyl or ethyl, and R.sup.3 and R.sup.4 are ##STR2## or H, and X is --C.dbd.O or --HC--OH,

Growing community of inventors

Shaker Heights, OH, United States of America

Henri Brunengraber