E. R. Squibb Sons, Inc.

Koster, William H.

Ermann, Peter H.

Sundeen, Joseph E.

Treuner, Uwe D.

Straub, Henner

Henner Straub

Peter H Ermann

Uwe D Treuner

Joseph E Sundeen

William H Koster

Sailesh A Varia

Jakob-Matthias Drossard

Michael Fakes

Kent Amsberry

Hermann Breuer

Joseph O'Sullivan

Douglas W Phillipson

Peter Hans Ermann

Uwe Dietmar Treuner

Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring.

Hereroaryl derivatives of monocyclic beta-lactam antibiotics

Antibacterial activity is exhibited by novel compounds having the formula ##STR1## where R.sub.1, R.sub.2, and M are as defined herein and X is --(CH.sub.2).sub.n -- wherein n is 0, 1, 2, 3 or 4 or CR.sub.3 R.sub.4 wherein R.sub.3 and R.sub.4 are the same or different and each is hydrogen, --CH.sub.3 or --C.sub.2 H.sub.5 or R.sub.3 and R.sub.4 taken together with the carbon atom to which they are attached form a 3, 4, 5, 6 or 7-membered cycloalkyl ring. Also described are various intermediates for the preparation of compounds of formula 1.

Intermediates for the preparation of heteroaryl derivatives of

Antibacterial activity has been found in compounds of the formula. Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: A is a bond or alkylene;

Heterocyclic hydrazide derivatives of monocyclic .beta.-lactam

Heteroaryl derivatives of monocyclic beta-lactam antibiotics

Novel antibiotic substances, including novel natural products, having the general formula ##STR1## wherein R.sub.1 and R.sub.2 are as defined herein, are disclosed. These compounds have been found to be cytochrome P450 inhibitors.

4-methoxy-5-methyl-pyran-3-ol natural products and derivatives thereof

Novel antibiotic substances, having the general formula ##STR1## wherein A, R.sub.1 and R.sub.2 are as defined herein.

Substituted pyran derivatives having antiinfective activity

Compounds having the formula ##STR1## exhibiting antibacterial activity.

Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.

2-oxoazetidin-1-yloxy acetic acids and analogs

Antibacterial activity is exhibited by .beta.-lactams having a 3-acylamino substituent and having in the 1-position an activating group of the formula ##STR1## wherein R is

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Wuppertal, Germany

Henner Straub